{"id":"W2886326884","doi":"10.1158/1538-7445.am2018-5575","title":"Abstract 5575: A multiplexed RE-qPCR cell-free DNA assay to assess response and resistance to cancer therapy","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Multiplex; Cell-free fetal DNA; Liquid biopsy; Biomarker; Real-time polymerase chain reaction; Cancer; Receiver operating characteristic; Biology; DNA; Molecular biology; Medicine; Computational biology; Bioinformatics; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002320413,0.001411348,0.00117146,0.002662042,0.0003114942,0.001049528,0.0009035071,0.001217871,0.00514843],"category_scores_gemma":[0.002371326,0.0005980138,0.0007638682,0.0008040839,0.0006197822,0.000470023,0.0005994584,0.0009956672,0.002411593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008089342,"about_ca_system_score_gemma":0.0005596021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007271109,"about_ca_topic_score_gemma":0.001271766,"domain_scores_codex":[0.9955817,0.0008945855,0.0002562588,0.001207382,0.001808804,0.0002512316],"domain_scores_gemma":[0.9987516,0.0004503246,0.0002511261,0.0001391211,0.0003307005,0.00007710425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004408708,0.0002485932,0.006484663,0.000329649,0.0001056067,0.00008752312,0.0001584914,0.001580345,0.9403429,0.0004918274,0.001831919,0.0478977],"study_design_scores_gemma":[0.00005001087,0.000961721,0.01169851,0.00007749692,0.0001519509,0.0004603897,0.00005212741,0.01204149,0.9627466,0.0002547014,0.01141763,0.0000873657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"other","genre_scores_codex":[0.4560911,0.01526662,0.4870246,0.0007024502,0.001104806,0.002877362,0.01392239,0.007337021,0.01567364],"genre_scores_gemma":[0.6111696,0.003511422,0.3233933,0.001250196,0.0002944262,0.00417512,0.009879664,0.0003566095,0.04596949],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.00514843,"threshold_uncertainty_score":0.01722324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08162189215095406,"score_gpt":0.4055351979438273,"score_spread":0.3239133057928733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}