{"id":"W2886327718","doi":"10.1158/1538-7445.am2018-4360","title":"Abstract 4360: Altering the regulation of KRAS GTPase cycle via Src and SHP2 creates a potential therapeutic vulnerability for pancreatic cancer","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"GTPase; KRAS; Guanine nucleotide exchange factor; Phosphorylation; Cell biology; Proto-oncogene tyrosine-protein kinase Src; Kinase; Chemistry; Cancer research; Effector; GTP'; Dephosphorylation; Biology; Biochemistry; Phosphatase; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007803643,0.000117944,0.0001418692,0.00004349581,0.0002577557,0.00004170718,0.0002432954,0.0001254246,0.000143629],"category_scores_gemma":[0.0001135892,0.00008357072,0.00007353675,0.000142307,0.0007499934,0.000006475314,0.0001755637,0.0001758813,0.00000190344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003882814,"about_ca_system_score_gemma":0.0001408566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001057998,"about_ca_topic_score_gemma":0.0002194184,"domain_scores_codex":[0.9985814,0.0001176678,0.0001872582,0.0003968921,0.0003081413,0.0004086286],"domain_scores_gemma":[0.9989499,0.00005289013,0.00004786486,0.0003824547,0.0004780222,0.00008891167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005426253,0.00004072649,0.0006578563,0.0001445739,0.00007740765,3.616755e-7,0.00006092991,0.00001836463,0.970042,0.00003106939,0.000362537,0.02802149],"study_design_scores_gemma":[0.000486392,0.0002940498,0.01434588,0.00004318988,0.00002027659,0.000002590375,0.00004358661,0.0007221722,0.9801199,0.001075222,0.002739022,0.0001077296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932824,0.004163704,0.001003509,0.0007216696,0.00005243801,0.0006008304,0.00004184995,0.000005847634,0.0001277358],"genre_scores_gemma":[0.9981893,0.0005661156,0.00008608492,0.00007485972,0.0004352353,0.0003748621,0.000024876,0.00002353182,0.0002251284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02791376,"threshold_uncertainty_score":0.3407915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04437062112946381,"score_gpt":0.3916740233982789,"score_spread":0.3473034022688151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}