{"id":"W2886347146","doi":"10.1089/scd.2018.0131","title":"Knockdown of p66Shc Alters Lineage-Associated Transcription Factor Expression in Mouse Blastocysts","year":2018,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Forskningsrådet om Hälsa, Arbetsliv och Välfärd","keywords":"Gene knockdown; Biology; Inner cell mass; Blastocyst; Transcription factor; Cell biology; Embryonic stem cell; MEF2C; Homeobox protein NANOG; Downregulation and upregulation; Molecular biology; Andrology; Embryogenesis; Embryo; Genetics; Cell culture; Induced pluripotent stem cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002073867,0.0001463971,0.0001717465,0.00008587565,0.00006070174,0.00001456603,0.0001185208,0.000142735,0.00002732002],"category_scores_gemma":[0.000005746062,0.0001304902,0.00003210909,0.00007822997,0.00007301893,0.000005795908,0.00009353083,0.00007069553,0.00001271993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003800247,"about_ca_system_score_gemma":0.0001024908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001454739,"about_ca_topic_score_gemma":0.00009838947,"domain_scores_codex":[0.9987975,0.00007477328,0.0003179565,0.0003238712,0.0002129701,0.0002729692],"domain_scores_gemma":[0.9995669,0.000009747021,0.00008413141,0.0001536346,0.00009161288,0.00009394293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001150348,0.00009261986,0.00176001,0.00005425158,0.00002054169,0.000001940776,0.000542915,0.000008254123,0.9941007,4.155386e-7,0.0002593552,0.003043954],"study_design_scores_gemma":[0.0008274991,0.0002032824,0.004484281,0.00006182636,0.000001732064,9.529285e-7,0.0001169043,0.00004370535,0.9865744,6.755352e-7,0.007534141,0.000150631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984186,0.0002285287,0.0006910884,0.0000124034,0.000103086,0.0002620181,0.00002390288,0.000007861267,0.0002524967],"genre_scores_gemma":[0.9969171,0.0001982927,0.0007575019,0.00002650364,0.00003113695,0.00001705258,0.00003759139,0.00001617663,0.001998651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007526338,"threshold_uncertainty_score":0.5321236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0182907894996399,"score_gpt":0.2481823114876512,"score_spread":0.2298915219880112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}