{"id":"W2886347146","doi":"10.1089/scd.2018.0131","title":"Knockdown of p66Shc Alters Lineage-Associated Transcription Factor Expression in Mouse Blastocysts","year":2018,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Forskningsrådet om Hälsa, Arbetsliv och Välfärd","keywords":"Gene knockdown; Biology; Inner cell mass; Blastocyst; Transcription factor; Cell biology; Embryonic stem cell; MEF2C; Homeobox protein NANOG; Downregulation and upregulation; Molecular biology; Andrology; Embryogenesis; Embryo; Genetics; Cell culture; Induced pluripotent stem cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001739781,0.0003043651,0.0002114103,0.0003087952,0.0001846814,0.0002847614,0.0001578662,0.00027608,0.001028339],"category_scores_gemma":[0.0001211074,0.0001747662,0.0001915637,0.0001685412,0.0002472397,0.0001908461,0.0001901994,0.0004886497,0.000342037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002541164,"about_ca_system_score_gemma":0.0002857589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008505316,"about_ca_topic_score_gemma":0.001196171,"domain_scores_codex":[0.999836,0.0000180646,0.00002466911,0.00003802027,0.00004639662,0.00003686773],"domain_scores_gemma":[0.9998755,0.00001872398,0.00004537069,0.00001359193,0.00001406053,0.00003270425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003748038,0.000007020045,0.00008018752,0.0000174276,0.000001738548,0.00001868033,0.000007479715,0.00002688434,0.9993463,0.00004949255,0.00001168516,0.0003954411],"study_design_scores_gemma":[0.000009905719,0.0001003199,0.003402517,0.00000433997,0.00001108505,0.00005302061,0.00002124822,0.0005381085,0.9949372,0.00002550039,0.0008944076,0.000002311214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939686,0.0009842225,0.003002803,0.00008185508,0.00002796252,0.00002904389,0.0005695328,0.00009301314,0.001242992],"genre_scores_gemma":[0.9928069,0.000878947,0.001965222,0.00005276137,0.000006222837,0.00005064439,0.0006411148,0.00003176737,0.003566275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001028339,"threshold_uncertainty_score":0.003440082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0182907894996399,"score_gpt":0.2481823114876512,"score_spread":0.2298915219880112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}