{"id":"W2886405078","doi":"10.1158/1538-7445.am2018-2720","title":"Abstract 2720: The CD47-blocking innate immune checkpoint inhibitor, TTI-621, triggers CD47-mediated tumor cell apoptosis","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trillium Therapeutics (Canada)","funders":"","keywords":"CD47; Apoptosis; Phagocytosis; Immune system; Flow cytometry; Cancer research; Macrophage; Antibody; Cell biology; Biology; Immunology; Molecular biology; Chemistry; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001090157,0.0004008791,0.0003364274,0.0001649761,0.0001330351,0.0002370191,0.0001743529,0.0002887432,0.003143665],"category_scores_gemma":[0.00009055517,0.0001066379,0.0002143428,0.000203466,0.0001290146,0.0001577106,0.0001328267,0.0006954412,0.0007552275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002850327,"about_ca_system_score_gemma":0.0003382553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006150174,"about_ca_topic_score_gemma":0.0006456083,"domain_scores_codex":[0.9998821,0.00001662524,0.00001167547,0.00001804938,0.00003084549,0.00004066994],"domain_scores_gemma":[0.9999599,0.000007929815,0.000007588782,0.000004770181,0.000005662003,0.00001412613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009754755,0.0002660531,0.0001918214,0.00009594715,0.00001227942,0.0001010324,0.0000160074,0.0001307165,0.9937235,0.0001225746,0.0006307992,0.003733751],"study_design_scores_gemma":[0.0002605189,0.001993353,0.002843936,0.00001043314,0.00002279581,0.0002734502,0.00002121005,0.001395576,0.9895743,0.00005834557,0.003542051,0.000004101682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880563,0.003453692,0.001667233,0.0002584643,0.0001198377,0.00009659634,0.0009474127,0.0001455075,0.005254966],"genre_scores_gemma":[0.9911999,0.001661828,0.001170888,0.000163103,0.00002773151,0.00009419396,0.001848251,0.00001873579,0.003815338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003143665,"threshold_uncertainty_score":0.01051664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04809370789063499,"score_gpt":0.3399361158854514,"score_spread":0.2918424079948164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}