{"id":"W2886413162","doi":"10.1158/1538-7445.am2018-10","title":"Abstract 10: Evaluation of metronomic chemotherapy regimens in preclinical orthotopically implanted colon cancer models, and in patient-derived xenografts","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Gemcitabine; Bevacizumab; Colorectal cancer; Internal medicine; Capecitabine; Regimen; Oncology; Cancer; Etoposide; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005484039,0.0006412684,0.0007461203,0.0003236623,0.0001935349,0.0005021735,0.0003758443,0.0005709284,0.002902552],"category_scores_gemma":[0.0002387879,0.0002421515,0.0004283691,0.0003638569,0.0002795732,0.0003263185,0.0001488909,0.001561686,0.0004538686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006935638,"about_ca_system_score_gemma":0.0006083704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002667859,"about_ca_topic_score_gemma":0.003854267,"domain_scores_codex":[0.9995334,0.0001256125,0.00003994796,0.00008775767,0.0001347394,0.00007856208],"domain_scores_gemma":[0.9996626,0.00007221066,0.00007037368,0.00006316829,0.00004548557,0.00008603997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002267692,0.002665757,0.0008841744,0.0001979502,0.00004697629,0.000118858,0.00008866206,0.00134799,0.9871256,0.0002027092,0.0009508767,0.004102784],"study_design_scores_gemma":[0.000381023,0.0199749,0.005520317,0.00001136215,0.00006743972,0.0003519153,0.00006127761,0.003522393,0.9658693,0.00004371599,0.004180796,0.00001554044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896186,0.001724231,0.002843924,0.0002195125,0.0001667778,0.000380695,0.002472639,0.0001732895,0.002400399],"genre_scores_gemma":[0.9862881,0.001184932,0.005110994,0.000102068,0.00002663403,0.0003142252,0.003120998,0.00006552947,0.003786545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002902552,"threshold_uncertainty_score":0.009709954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1421376330490395,"score_gpt":0.4781424179465738,"score_spread":0.3360047848975344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}