{"id":"W2886443841","doi":"10.1016/j.aca.2018.08.006","title":"Highly sensitive fluorescent bioassay of 2,3,7,8-tetrachloro-dibenzo-p-dioxin based on abnormal expression of cytochrome P450 1A2 in human cells","year":2018,"lang":"en","type":"article","venue":"Analytica Chimica Acta","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Education and Child Care","funders":"National Natural Science Foundation of China","keywords":"CYP1A2; Bioassay; Chemistry; In vitro; Cytochrome P450; Fluorescence; Cytochrome; CYP1B1; Molecular biology; Carcinogen; Biochemistry; Enzyme; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003240346,0.0003346676,0.0002327436,0.0003601323,0.0002269393,0.0002514818,0.0002737705,0.0004873628,0.001035823],"category_scores_gemma":[0.0002238588,0.0002240722,0.000227798,0.0003675577,0.0002671551,0.0001877475,0.0002351275,0.0005160851,0.0003848866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002672412,"about_ca_system_score_gemma":0.0001810164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007137923,"about_ca_topic_score_gemma":0.0009352231,"domain_scores_codex":[0.9996094,0.0001148824,0.00002235634,0.00009006548,0.0001030815,0.00006015088],"domain_scores_gemma":[0.9998518,0.00005300099,0.00001423219,0.00002830229,0.0000329684,0.0000195941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005504948,0.00001540265,0.0002930088,0.00001089044,0.000004548496,0.00003844044,0.00003728829,0.00002787254,0.9988692,0.00007708032,0.00003515984,0.0005360317],"study_design_scores_gemma":[0.00001005435,0.0001471118,0.002504084,0.000001850152,0.00001730176,0.0002047709,0.00002602248,0.0005486918,0.9957976,0.00006729412,0.0006722418,0.000002847233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9498168,0.003215295,0.04179711,0.0002413789,0.00008286486,0.00006875073,0.0006496286,0.0002309758,0.003897112],"genre_scores_gemma":[0.9854762,0.0009771823,0.009246008,0.00007780627,0.00001809845,0.00007523679,0.0009611339,0.00001668961,0.003151542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001035823,"threshold_uncertainty_score":0.003465116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008884274713526631,"score_gpt":0.2386705587049448,"score_spread":0.2297862839914182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}