{"id":"W2886448521","doi":"10.2147/dddt.s171269","title":"Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus","year":2018,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"National Research Foundation of Korea; Ministry of Science, ICT and Future Planning; National Research Foundation","keywords":"Oncolytic virus; Medicine; Cirrhosis; Vaccinia; Hepatocellular carcinoma; Liver cancer; Cancer; Pathology; Internal medicine; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00230089,0.0001213669,0.0001806855,0.00006205431,0.00006960232,0.000007953699,0.0001362928,0.00009093726,0.0001309377],"category_scores_gemma":[0.00006823221,0.0001038364,0.00003815705,0.00009151475,0.0001649293,0.000004528915,0.00004595797,0.00004413848,0.000005593135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001852464,"about_ca_system_score_gemma":0.0005097291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005742293,"about_ca_topic_score_gemma":0.00002951135,"domain_scores_codex":[0.9984584,0.0003853343,0.0003857166,0.0002330205,0.0003820054,0.0001555392],"domain_scores_gemma":[0.9992265,0.00004916689,0.0001352656,0.0002192262,0.0003174354,0.00005245665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007309085,0.0001212122,0.000715022,0.00000890569,0.00009454799,1.58851e-7,0.0006171419,0.000008877771,0.7568615,0.000003791603,0.0001084973,0.2341513],"study_design_scores_gemma":[0.002785488,0.001863885,0.004219547,0.00002448833,0.0000114903,9.209168e-7,0.0000266621,0.0003827182,0.9880927,0.0001700542,0.002297303,0.0001246971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971246,0.0008926919,0.001092109,0.00003561577,0.00009994293,0.0005414032,0.000002654275,0.00000478653,0.0002062188],"genre_scores_gemma":[0.9967496,0.0008321001,0.002066563,0.00006049453,0.0001228919,0.00003179194,0.00003034401,0.00001497111,0.0000912711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2340266,"threshold_uncertainty_score":0.4234328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07173052238067792,"score_gpt":0.3580955501735473,"score_spread":0.2863650277928694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}