{"id":"W2886448521","doi":"10.2147/dddt.s171269","title":"Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus","year":2018,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"National Research Foundation of Korea; Ministry of Science, ICT and Future Planning; National Research Foundation","keywords":"Oncolytic virus; Medicine; Cirrhosis; Vaccinia; Hepatocellular carcinoma; Liver cancer; Cancer; Pathology; Internal medicine; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001006623,0.0006369943,0.0004504412,0.0004300218,0.0002193195,0.0004595122,0.0004443001,0.0004905431,0.001699898],"category_scores_gemma":[0.0007057129,0.0001947862,0.0003698462,0.0002055428,0.0005829931,0.0004637857,0.000170446,0.001116964,0.000319914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004278147,"about_ca_system_score_gemma":0.0005475205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005996624,"about_ca_topic_score_gemma":0.0005221325,"domain_scores_codex":[0.9996322,0.0001110839,0.00003278969,0.00005539457,0.00009665389,0.00007187367],"domain_scores_gemma":[0.9994123,0.0001225865,0.000185642,0.00008235205,0.0001041521,0.00009298317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004533384,0.003389482,0.00129691,0.0002688056,0.00006152954,0.0001469983,0.00013234,0.00163009,0.9726568,0.0004285477,0.0004684303,0.01498665],"study_design_scores_gemma":[0.000360867,0.07559328,0.003543048,0.00004633538,0.0001814142,0.0003413702,0.00008144531,0.004631208,0.9101909,0.0001583882,0.004853115,0.00001863785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832882,0.002242266,0.01039907,0.0001767734,0.0001403265,0.0006909839,0.0005386276,0.0001448891,0.002378951],"genre_scores_gemma":[0.9886677,0.00247379,0.005155396,0.00008452393,0.00007060367,0.0005593725,0.0007775204,0.0000316862,0.002179438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001699898,"threshold_uncertainty_score":0.0056867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07173052238067792,"score_gpt":0.3580955501735473,"score_spread":0.2863650277928694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}