{"id":"W2886480505","doi":"10.1016/j.chembiol.2018.07.009","title":"Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site","year":2018,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Connaught Fund; Canada Foundation for Innovation; Princess Margaret Cancer Foundation; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Effector; Mechanism (biology); Mechanism of action; Chemistry; Membrane; Biophysics; Cell biology; Stereochemistry; Biology; Biochemistry; Philosophy; Epistemology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003309431,0.000532121,0.0004733864,0.0002443842,0.000308048,0.0006193146,0.0005710438,0.0005235543,0.001986522],"category_scores_gemma":[0.000262917,0.0002697259,0.0004219882,0.0001302038,0.0005454824,0.0002653176,0.0003645876,0.000943786,0.0007328609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000565232,"about_ca_system_score_gemma":0.0003980465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005469376,"about_ca_topic_score_gemma":0.0006947195,"domain_scores_codex":[0.9997761,0.00003369454,0.00001696399,0.00003876133,0.00006716391,0.00006732615],"domain_scores_gemma":[0.9998773,0.00002577269,0.00003141666,0.00002309965,0.00001510142,0.00002712327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001835896,0.00002850225,0.00007436502,0.00003363842,0.00001219773,0.00005035198,0.00001108456,0.0001251605,0.9970635,0.0006597855,0.00006596989,0.001691848],"study_design_scores_gemma":[0.00002327736,0.00007282758,0.0002753781,0.000001714977,0.000007191951,0.0001074035,0.000004949706,0.0008087741,0.9971245,0.00005469843,0.001515634,0.000003601156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817484,0.001548668,0.01152773,0.0004484828,0.0001508328,0.00006334449,0.0002207238,0.0004927982,0.003798994],"genre_scores_gemma":[0.9954655,0.0003190615,0.002278273,0.00004866751,0.00001296542,0.00002697006,0.0001099413,0.00003408435,0.001704651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001986522,"threshold_uncertainty_score":0.00664562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008455948957817877,"score_gpt":0.2431331716847036,"score_spread":0.2346772227268857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}