{"id":"W2886489059","doi":"10.1111/cei.13145","title":"Infusion of<i>ex-vivo</i>expanded human TCR-αβ+ double-negative regulatory T cells delays onset of xenogeneic graft-<i>versus</i>-host disease","year":2018,"lang":"en","type":"article","venue":"Clinical & Experimental Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Ex vivo; In vivo; Immunology; T cell; Immune system; T-cell receptor; Humanized mouse; Regulatory T cell; Graft-versus-host disease; Biology; Medicine; Cancer research; Stem cell; Cell biology; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007355755,0.0003929751,0.001160858,0.0002532914,0.0001814579,0.00001206327,0.0005038974,0.0004419779,0.00770278],"category_scores_gemma":[0.000187723,0.0003599057,0.0006062866,0.0003672215,0.004612701,0.0001123994,0.0006282881,0.0006078981,0.0001806944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002051078,"about_ca_system_score_gemma":0.0003557561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002699945,"about_ca_topic_score_gemma":0.00002827808,"domain_scores_codex":[0.9959718,0.0005116666,0.001539072,0.0007770919,0.0005601872,0.0006401576],"domain_scores_gemma":[0.996592,0.0006905983,0.0005027331,0.001388908,0.000402995,0.0004227431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0356997,0.002501798,0.004210111,0.00004086453,0.0006241885,0.00005403847,0.0007954454,3.84449e-7,0.9538927,0.0003027204,0.00128165,0.000596402],"study_design_scores_gemma":[0.01833028,0.009287831,0.02093931,0.0001379394,0.0001510712,0.00001609857,0.0008551404,0.00001304672,0.9473456,0.00009520668,0.002540899,0.0002875448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924088,0.001671831,0.000006212069,0.0001714804,0.001146338,0.00105156,0.00006155294,0.00007033909,0.003411954],"genre_scores_gemma":[0.996303,0.0003116792,0.0002576246,0.0003047454,0.0003541382,0.00006118674,0.00007509819,0.00007727891,0.002255301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01736941,"threshold_uncertainty_score":0.9998853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07825711958929048,"score_gpt":0.4253936153235808,"score_spread":0.3471364957342903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}