{"id":"W2886497950","doi":"10.1038/s41467-018-05427-7","title":"Identification of nine new susceptibility loci for endometrial cancer","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":326,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services","funders":"National Cancer Institute; National Health and Medical Research Council; Medical Research Council; National Institutes of Health; Vincent Fairfax Family Foundation; Haukeland Universitetssjukehus; Norges Forskningsråd; Universitetet i Bergen; Helse Vest; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Karolinska Institutet; Cancer Council Queensland; Ministerio de Economía y Competitividad; Canadian Institutes of Health Research; Cancerfonden; Agency for Science, Technology and Research; Hunter Medical Research Institute; National Institute on Aging; National Institute for Health and Care Research; National Heart, Lung, and Blood Institute; Fred C. and Katherine B. Andersen Foundation; Cancer Research UK; Wellcome Trust; Breast Cancer Research Foundation; University of Cambridge; Kreftforeningen; U.S. Public Health Service; Genome Canada; Mayo Foundation for Medical Education and Research; Cancer Council Tasmania; Brigham and Women's Hospital; Women's Health Initiative; Roswell Park Cancer Institute; Fred Hutchinson Cancer Research Center; U.S. Department of Health and Human Services; Ovarian Cancer Research Fund; Stockholms Läns Landsting; QIMR Berghofer Medical Research Institute; European Commission; Susan G. Komen for the Cure","keywords":"Endometrial cancer; Genome-wide association study; Expression quantitative trait loci; Locus (genetics); Biology; Quantitative trait locus; Genetics; Allele; Genetic association; Candidate gene; Gene; Genotype; Colorectal cancer; Cancer; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003976237,0.00008878315,0.0001156346,0.00008954026,0.0001388197,0.00001551103,0.0008292875,0.0003306252,0.00005948608],"category_scores_gemma":[0.001043361,0.00009290322,0.0001079715,0.000341472,0.0002022004,0.000004210371,0.0002769595,0.0002497151,0.000004825019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004530165,"about_ca_system_score_gemma":0.0003065577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009525612,"about_ca_topic_score_gemma":0.001832853,"domain_scores_codex":[0.9990886,0.00008660688,0.0002694331,0.0002447742,0.0001540178,0.0001565564],"domain_scores_gemma":[0.9973193,0.00005627359,0.0001459106,0.001716913,0.000695845,0.00006571436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001445968,0.00006329575,0.0000767887,0.000009235538,0.00006647456,1.592035e-8,0.00003111189,0.000008962674,0.9741133,0.001427918,0.01883907,0.005219219],"study_design_scores_gemma":[0.0007810306,0.0001901287,0.0003845435,0.000006944805,0.00003188054,8.482745e-7,0.0000180317,0.0002964382,0.8351183,0.0002637561,0.1628174,0.00009073317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2418892,0.09044674,0.6294312,0.01903393,0.0034701,0.008043912,0.002013442,0.000165264,0.005506102],"genre_scores_gemma":[0.9926069,0.0009561846,0.004220433,0.0001134686,0.0004383542,0.000101281,0.0004064886,0.00002015154,0.001136695],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7507177,"threshold_uncertainty_score":0.3788483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02931208848193555,"score_gpt":0.382064886824997,"score_spread":0.3527527983430614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}