{"id":"W2886497950","doi":"10.1038/s41467-018-05427-7","title":"Identification of nine new susceptibility loci for endometrial cancer","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":326,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services","funders":"National Cancer Institute; National Health and Medical Research Council; Medical Research Council; National Institutes of Health; Vincent Fairfax Family Foundation; Haukeland Universitetssjukehus; Norges Forskningsråd; Universitetet i Bergen; Helse Vest; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Karolinska Institutet; Cancer Council Queensland; Ministerio de Economía y Competitividad; Canadian Institutes of Health Research; Cancerfonden; Agency for Science, Technology and Research; Hunter Medical Research Institute; National Institute on Aging; National Institute for Health and Care Research; National Heart, Lung, and Blood Institute; Fred C. and Katherine B. Andersen Foundation; Cancer Research UK; Wellcome Trust; Breast Cancer Research Foundation; University of Cambridge; Kreftforeningen; U.S. Public Health Service; Genome Canada; Mayo Foundation for Medical Education and Research; Cancer Council Tasmania; Brigham and Women's Hospital; Women's Health Initiative; Roswell Park Cancer Institute; Fred Hutchinson Cancer Research Center; U.S. Department of Health and Human Services; Ovarian Cancer Research Fund; Stockholms Läns Landsting; QIMR Berghofer Medical Research Institute; European Commission; Susan G. Komen for the Cure","keywords":"Endometrial cancer; Genome-wide association study; Expression quantitative trait loci; Locus (genetics); Biology; Quantitative trait locus; Genetics; Allele; Genetic association; Candidate gene; Gene; Genotype; Colorectal cancer; Cancer; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001778643,0.000757665,0.001098192,0.002112396,0.0003905355,0.00120621,0.0008149678,0.0008089615,0.003471162],"category_scores_gemma":[0.003823412,0.0005762626,0.002605751,0.002390074,0.0003826197,0.0003567079,0.0008440989,0.0008770675,0.0003683722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003519687,"about_ca_system_score_gemma":0.000456676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00193409,"about_ca_topic_score_gemma":0.002724194,"domain_scores_codex":[0.9988839,0.0002476194,0.0001152461,0.0004098591,0.0002258145,0.0001175905],"domain_scores_gemma":[0.9978055,0.001046674,0.0004516552,0.0003259821,0.0001837087,0.000186565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003154689,0.0001176877,0.8736854,0.0006734086,0.009011551,0.004408367,0.0003216732,0.001489981,0.04516061,0.001128833,0.00141299,0.05943475],"study_design_scores_gemma":[0.0006877391,0.0003968241,0.9690166,0.0001147483,0.007530815,0.004541059,0.0001524209,0.002545352,0.004925807,0.002533391,0.007478088,0.00007721577],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9651667,0.02017813,0.008623539,0.000799732,0.0001653455,0.00005534457,0.003227674,0.0002120546,0.001571433],"genre_scores_gemma":[0.9866011,0.003887357,0.006024532,0.0002609016,0.0001617022,0.00004470447,0.002147522,0.00004840284,0.000823911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003471162,"threshold_uncertainty_score":0.01161224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02931208848193555,"score_gpt":0.382064886824997,"score_spread":0.3527527983430614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}