{"id":"W2886518982","doi":"10.1158/1538-7445.am2018-4318","title":"Abstract 4318: Identifying drivers of SMARCA4/BRG1-deficient SCCOHT tumorigenesis by integrative multi-omic analysis","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"SMARCA4; Biology; Carcinogenesis; SWI/SNF; Chromatin remodeling; Transcription factor; Gene; Gene expression; Chromatin; Transcriptome; Cancer research; Genetics; Cell biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006908547,0.0001588976,0.0002508875,0.0002331782,0.0002026273,0.00004223097,0.0004047573,0.0001243655,0.000324025],"category_scores_gemma":[0.0001110561,0.0001397169,0.0002005971,0.0007420319,0.0004911025,0.000006338766,0.0001678262,0.0001996088,0.0000248243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001667106,"about_ca_system_score_gemma":0.0003181119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003119608,"about_ca_topic_score_gemma":0.001556312,"domain_scores_codex":[0.9981521,0.0001051548,0.0002944449,0.0005407376,0.0004727675,0.0004348264],"domain_scores_gemma":[0.9985178,0.00003060042,0.0001115636,0.0004767383,0.0007438184,0.0001194798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008968865,0.00007246316,0.003298969,0.00004009693,0.0004410707,0.000001296337,0.0004085981,0.000363479,0.9859543,0.00000581677,0.006484448,0.00283976],"study_design_scores_gemma":[0.0004812205,0.0001398082,0.00442961,0.00006397039,0.00008949052,6.673933e-7,0.0011244,0.001413545,0.9885277,0.00001519962,0.003522477,0.0001919739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928211,0.00266878,0.003416582,0.00008083165,0.0001512568,0.0001791715,0.0001379751,0.00001026137,0.0005340734],"genre_scores_gemma":[0.99686,0.0009908475,0.000291897,0.00003288743,0.0001834417,0.00005655596,0.0000839046,0.00002424477,0.001476165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004038988,"threshold_uncertainty_score":0.5697491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0688615713162637,"score_gpt":0.4261220681609477,"score_spread":0.357260496844684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}