{"id":"W2886518982","doi":"10.1158/1538-7445.am2018-4318","title":"Abstract 4318: Identifying drivers of SMARCA4/BRG1-deficient SCCOHT tumorigenesis by integrative multi-omic analysis","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"SMARCA4; Biology; Carcinogenesis; SWI/SNF; Chromatin remodeling; Transcription factor; Gene; Gene expression; Chromatin; Transcriptome; Cancer research; Genetics; Cell biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004831214,0.0006596686,0.0008560854,0.001759718,0.0006079377,0.0008257244,0.0006994012,0.0005992234,0.005509883],"category_scores_gemma":[0.0003055997,0.0003824497,0.001038674,0.001116032,0.0003456026,0.0002284152,0.0007614314,0.001127317,0.002285384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006865034,"about_ca_system_score_gemma":0.0006356566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001956533,"about_ca_topic_score_gemma":0.003671035,"domain_scores_codex":[0.9994535,0.00002719952,0.0000330785,0.0001699855,0.000230097,0.00008615908],"domain_scores_gemma":[0.999701,0.00004128885,0.00009434822,0.00004123365,0.00004898934,0.00007313248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001598944,0.00004600192,0.004331866,0.0002286152,0.00007704055,0.0003686429,0.00006161581,0.0003844578,0.9864838,0.0004656849,0.00100354,0.006388894],"study_design_scores_gemma":[0.0001485318,0.0004923547,0.149117,0.0001424231,0.0005902793,0.003575632,0.0003588578,0.01542248,0.755151,0.001103071,0.07381105,0.00008731594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8450364,0.003834557,0.05846783,0.0006502073,0.0003005861,0.0004904892,0.0778821,0.004594294,0.008743519],"genre_scores_gemma":[0.8420157,0.002188059,0.04982706,0.0007978193,0.00005848842,0.0005800711,0.09025853,0.002421065,0.01185313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005509883,"threshold_uncertainty_score":0.01843238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0688615713162637,"score_gpt":0.4261220681609477,"score_spread":0.357260496844684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}