{"id":"W2886522468","doi":"10.1158/1538-7445.am2018-3673","title":"Abstract 3673: Targeting the epigenome of small cell hypercalcemic carcinoma of the ovary, hypercalcemic type (SCCOHT)","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"SMARCA4; Biology; Epigenome; Cancer research; Chromatin remodeling; EZH2; Chromatin; Epigenetics; Cell cycle checkpoint; Histone; Cell cycle; Cell biology; Cancer; Genetics; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007988053,0.0001271831,0.0001613148,0.00003997834,0.0002059217,0.00001288501,0.0007371841,0.0001381143,0.0001549456],"category_scores_gemma":[0.0001344296,0.00007814469,0.000118902,0.0003109995,0.0006297834,0.000002750663,0.0003144975,0.0003083512,0.00001416028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006015481,"about_ca_system_score_gemma":0.0006144558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001308955,"about_ca_topic_score_gemma":0.0001357561,"domain_scores_codex":[0.9985131,0.0001383987,0.0002972814,0.00031145,0.0003442708,0.0003954711],"domain_scores_gemma":[0.9984536,0.00005588151,0.0001086776,0.0006882932,0.000634282,0.00005931891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001356232,0.00003166287,0.003731615,0.00008510037,0.0000261029,4.61423e-7,0.0002260068,0.0001100204,0.9916446,0.000009466551,0.002759505,0.001239836],"study_design_scores_gemma":[0.0003138387,0.0002108757,0.008154817,0.00005583453,0.00001436188,0.000002399198,0.0002809408,0.000146354,0.9821327,0.0000665068,0.008508828,0.0001125334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899429,0.006662715,0.00001650753,0.0001987687,0.0002535227,0.0002515035,0.00002863955,0.000004593768,0.002640866],"genre_scores_gemma":[0.9976495,0.0007572304,0.0000886253,0.00007819931,0.0005854754,0.000023251,0.00001000784,0.00003111644,0.0007765808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00951189,"threshold_uncertainty_score":0.3186648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05717682523361722,"score_gpt":0.3411357614902597,"score_spread":0.2839589362566425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}