{"id":"W2886523444","doi":"10.1101/383331","title":"The genetics of the mood disorder spectrum: genome-wide association analyses of over 185,000 cases and 439,000 controls","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; National Health and Medical Research Council; Stanley Center for Psychiatric Research, Broad Institute; University of California, San Diego; National Institutes of Health; Ministry of Cultural Affairs; H. Lundbeck A/S; Medical Research Council; Siemens Healthineers; Chinese Society of Clinical Oncology; Novo Nordisk Fonden; NSW Ministry of Health; Vetenskapsrådet; Region Hovedstaden; Novo Nordisk; European Regional Development Fund; King's College London; Max-Planck-Gesellschaft; Center for Individualized Medicine, Mayo Clinic; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Generalitat de Catalunya; Stanley Medical Research Institute; Bundesministerium für Bildung und Forschung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Universität Greifswald; Agence Nationale de la Recherche; Canadian Institutes of Health Research; Office of Health and Medical Research; Rheinische Friedrich-Wilhelms-Universität Bonn; Scottish Funding Council; European Commission; Broad Institute; QIMR Berghofer Medical Research Institute; Norges Forskningsråd; Erasmus Medisch Centrum; Stiftelsen för Strategisk Forskning; Neuroscience Research Australia; Wellcome Trust; Karolinska Institutet; ZonMw; National Alliance for Research on Schizophrenia and Depression; National Institute on Drug Abuse; South London and Maudsley NHS Foundation Trust; National Institute on Alcohol Abuse and Alcoholism; Stockholms Läns Landsting; Højteknologifonden; Lundbeckfonden; State University of New York; Kaiser Permanente; Instituto de Salud Carlos III; Ellison Medical Foundation; U.S. Department of Health and Human Services; Mayo Clinic; GlaxoSmithKline; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Wayne and Gladys Valley Foundation; Departament de Salut, Generalitat de Catalunya; National Science Foundation; University of Michigan; Cilag; Robert Wood Johnson Foundation; Pfizer; Westfälische Wilhelms-Universität Münster; National Institute on Aging; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España","keywords":"Bipolar disorder; Major depressive disorder; Mood disorders; Genome-wide association study; Mood; Depression (economics); Psychiatry; Genetic association; Psychology; Bipolar II disorder; Clinical psychology; Genetics; Genotype; Biology; Single-nucleotide polymorphism; Anxiety; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00344708,0.0004647661,0.0009205179,0.001674763,0.0009917652,0.001225752,0.0006613715,0.0008466613,0.001942375],"category_scores_gemma":[0.004877646,0.0005969006,0.001914245,0.003470547,0.0004446335,0.0002967559,0.0009192104,0.0006773744,0.0002046534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004503087,"about_ca_system_score_gemma":0.0004422758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01417934,"about_ca_topic_score_gemma":0.01477322,"domain_scores_codex":[0.9961308,0.001192689,0.000452767,0.001543787,0.0004597245,0.0002202551],"domain_scores_gemma":[0.9979599,0.0008145339,0.0004941679,0.0003822642,0.0001823285,0.000166787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009040603,0.00005391324,0.9846309,0.0001303076,0.006991089,0.0005063378,0.0001810357,0.0002292958,0.001737366,0.0001135708,0.000739649,0.0037825],"study_design_scores_gemma":[0.0001711814,0.00009660594,0.994317,0.00002825367,0.003347503,0.0004068608,0.00011319,0.0004405306,0.0001758091,0.000105598,0.0007872102,0.00001024093],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908201,0.003996176,0.00143411,0.0001565024,0.00003653786,0.00003827554,0.00304971,0.00003854055,0.0004301508],"genre_scores_gemma":[0.9970861,0.0005181293,0.0006430047,0.00006807958,0.00002607715,0.00004082685,0.001458562,0.00001269535,0.0001465866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01417934,"threshold_uncertainty_score":0.02819365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01279087361172394,"score_gpt":0.2510432972585366,"score_spread":0.2382524236468127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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