{"id":"W2886557345","doi":"10.1158/1535-7163.targ-17-a100","title":"Abstract A100: Seamless phase I/II clinical trials in oncology: retrospective analysis of the last 7 years","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Queen's University; McMaster University","funders":"","keywords":"Medicine; Clinical trial; Internal medicine; Phases of clinical research; Clinical Oncology; Population; Oncology; Food and drug administration; Cancer; Drug development; Sample size determination; Drug; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03823971,0.0005312149,0.001329537,0.009090607,0.0006463801,0.002590853,0.001001187,0.0007944661,0.002750546],"category_scores_gemma":[0.109259,0.0006728788,0.002193516,0.01240022,0.001075859,0.002465551,0.001598689,0.0009998427,0.0009401342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001019494,"about_ca_system_score_gemma":0.002242607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001098372,"about_ca_topic_score_gemma":0.001290562,"domain_scores_codex":[0.9429981,0.01776195,0.02532024,0.004368726,0.008665863,0.0008851278],"domain_scores_gemma":[0.7029062,0.1049112,0.1466066,0.01990057,0.02137585,0.004299687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002525244,0.0001170669,0.9530248,0.005097115,0.003170621,0.0005093148,0.0002896838,0.0004136723,0.0007729043,0.0004993068,0.005132983,0.02844723],"study_design_scores_gemma":[0.0006398152,0.00146237,0.9468837,0.004060281,0.004868295,0.004952633,0.0006817532,0.0007907699,0.001458184,0.0005030187,0.03361416,0.00008484297],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7616736,0.1682402,0.01287642,0.001470689,0.0003271757,0.003771588,0.04453542,0.0002090361,0.006895869],"genre_scores_gemma":[0.9612762,0.01464425,0.004559768,0.001127061,0.0003468234,0.002812831,0.01453427,0.0001138354,0.0005849036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03823971,"threshold_uncertainty_score":0.2022333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06756027576180723,"score_gpt":0.4308483398892855,"score_spread":0.3632880641274783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}