{"id":"W2886592807","doi":"10.6004/jnccn.2018.7020","title":"DNA Repair Gene Alterations and PARP Inhibitor Response in Patients With Metastatic Castration-Resistant Prostate Cancer","year":2018,"lang":"en","type":"article","venue":"Journal of the National Comprehensive Cancer Network","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Cilag; National Cancer Institute; Janssen Biotech; Astellas Pharma; Celgene; University of Michigan; Valeant Pharmaceuticals International; Varian Medical Systems; Gilead Sciences","keywords":"DNA repair; PARP inhibitor; Prostate cancer; Medicine; Cancer research; Mutation; Cancer; Poly ADP ribose polymerase; Gene; Homologous recombination; DNA damage; Gene mutation; Oncology; Internal medicine; DNA; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002733604,0.000145963,0.0002739943,0.0001346556,0.000215009,0.00003431701,0.00007710631,0.00003231533,0.00004655845],"category_scores_gemma":[0.00008761584,0.00008447182,0.0000768453,0.000505204,0.0002180072,0.0001639704,0.00003828826,0.0002495809,0.000001004376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005493316,"about_ca_system_score_gemma":0.001081604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002788565,"about_ca_topic_score_gemma":0.0001162402,"domain_scores_codex":[0.9982055,0.0002075057,0.0004157364,0.000170004,0.0007734857,0.0002277181],"domain_scores_gemma":[0.9966088,0.0002061461,0.0003190884,0.00009835432,0.00265359,0.0001140519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1687761,0.0009501302,0.712639,0.0002586003,0.002811925,0.0001354123,0.003273715,0.02463704,0.02799454,0.0001865807,0.05639335,0.001943596],"study_design_scores_gemma":[0.007379724,0.001676293,0.9822709,0.0007597494,0.0001682879,0.00003543312,0.00007675061,0.0004285361,0.001369229,0.000242284,0.005462284,0.0001305161],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991898,0.003430187,0.00000510108,0.003561326,0.0003734228,0.0006173319,0.00007769282,0.000006842214,0.00003010885],"genre_scores_gemma":[0.9966815,0.0003056995,0.0008651983,0.0009168125,0.0008467913,0.00005053302,0.000008793498,0.00001784481,0.0003068979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.269632,"threshold_uncertainty_score":0.3444661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.035890937354533,"score_gpt":0.3342492008840909,"score_spread":0.2983582635295579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}