{"id":"W2886592807","doi":"10.6004/jnccn.2018.7020","title":"DNA Repair Gene Alterations and PARP Inhibitor Response in Patients With Metastatic Castration-Resistant Prostate Cancer","year":2018,"lang":"en","type":"article","venue":"Journal of the National Comprehensive Cancer Network","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Cilag; National Cancer Institute; Janssen Biotech; Astellas Pharma; Celgene; University of Michigan; Valeant Pharmaceuticals International; Varian Medical Systems; Gilead Sciences","keywords":"DNA repair; PARP inhibitor; Prostate cancer; Medicine; Cancer research; Mutation; Cancer; Poly ADP ribose polymerase; Gene; Homologous recombination; DNA damage; Gene mutation; Oncology; Internal medicine; DNA; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004826942,0.0001583335,0.0002506796,0.0004938648,0.0002444003,0.0002984816,0.0001872821,0.0002575785,0.001036507],"category_scores_gemma":[0.00174019,0.0001149201,0.0001860949,0.0005374116,0.0001789024,0.0001995496,0.0001294836,0.0003583636,0.0001220977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003314603,"about_ca_system_score_gemma":0.0002709703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001064077,"about_ca_topic_score_gemma":0.00150361,"domain_scores_codex":[0.9997131,0.00009096536,0.00003312903,0.0000535507,0.00006265328,0.00004650862],"domain_scores_gemma":[0.9987663,0.0003964084,0.000551726,0.00002802042,0.00007912759,0.0001784141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003653213,0.00007371537,0.994495,0.00001502204,0.00002450202,0.0003542132,0.00005001254,0.000124612,0.001091584,0.00001020627,0.00009867537,0.003297181],"study_design_scores_gemma":[0.00003778624,0.001069351,0.9924467,0.000008492727,0.00004996882,0.004290394,0.0001416825,0.0005261309,0.001028177,0.00002744615,0.0003666739,0.000007202379],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993032,0.0003540711,0.00006872485,0.00003542487,0.000002227259,0.000005984552,0.00006931891,0.000004915736,0.0001561094],"genre_scores_gemma":[0.9997032,0.00008235466,0.00008033452,0.00001892272,0.000006691336,0.000003000094,0.00007352216,0.000001072154,0.00003084886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001064077,"threshold_uncertainty_score":0.003467441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.035890937354533,"score_gpt":0.3342492008840909,"score_spread":0.2983582635295579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}