{"id":"W2886633519","doi":"10.1158/1538-7445.am2018-4322","title":"Abstract 4322: Atrx inactivation drives motility and dysregulates differentiation in glioma cells of origin through global epigenomic remodeling","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"ATRX; Biology; Epigenomics; Chromatin; Epigenetics; Death-associated protein 6; Genetics; Chromatin remodeling; Phenotype; Cancer research; Cell biology; DNA methylation; Gene; Mutation; Gene expression; Transcription factor; Nuclear protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006318622,0.0002626938,0.0001676153,0.0002140781,0.0001099126,0.000235835,0.0001572663,0.0001742535,0.001887897],"category_scores_gemma":[0.0000400622,0.000124497,0.0001634042,0.0001514504,0.0001550263,0.00008243158,0.0002022362,0.0004102187,0.0007870612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002033242,"about_ca_system_score_gemma":0.0001525899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009289012,"about_ca_topic_score_gemma":0.001204344,"domain_scores_codex":[0.9999089,0.00001062014,0.000008490239,0.00002684522,0.00002503419,0.000020158],"domain_scores_gemma":[0.999941,0.000006963254,0.00001841952,0.0000113473,0.000004982107,0.00001718036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002861747,0.00000556373,0.000106968,0.000008431787,0.000001543824,0.00003037518,0.000005157695,0.00002280777,0.9993818,0.00004145967,0.00001949738,0.0003478176],"study_design_scores_gemma":[0.000007470103,0.0001218755,0.008656031,0.000003914344,0.00000910878,0.0002361134,0.00002649114,0.0007949227,0.9878541,0.0000318991,0.002255769,0.00000242894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931841,0.0008231017,0.002751279,0.00007284175,0.00001893017,0.00001836817,0.001080336,0.0001879765,0.001863124],"genre_scores_gemma":[0.992021,0.0005126293,0.001345853,0.00004329088,0.000004632492,0.00002874231,0.001214583,0.00005186535,0.004777388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001887897,"threshold_uncertainty_score":0.006315589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04464081322358235,"score_gpt":0.3629849410242407,"score_spread":0.3183441278006583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}