{"id":"W2886637264","doi":"10.1186/s40814-018-0327-z","title":"Study protocol: a randomized, double-blind, parallel, two-arm, placebo control trial investigating the feasibility and safety of immunoglobulin treatment in COPD patients for prevention of frequent recurrent exacerbations","year":2018,"lang":"en","type":"article","venue":"Pilot and Feasibility Studies","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Clinical Evaluative Sciences; Ottawa Public Health; Ottawa Hospital; University of Ottawa","funders":"Ottawa Hospital Research Institute; Grifols; CSL Behring","keywords":"Medicine; Exacerbation; COPD; Tolerability; Randomized controlled trial; Quality of life (healthcare); Adverse effect; Placebo; Randomization; Intensive care medicine; Clinical trial; Internal medicine; Physical therapy; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0028015,0.0002875016,0.001252856,0.00009889255,0.0002639694,0.00001612848,0.00009309735,0.00004420005,0.0000110568],"category_scores_gemma":[0.001881458,0.0001777729,0.0001839091,0.0002151895,0.001545038,0.0001018717,0.0001380691,0.0001395265,3.816366e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000571726,"about_ca_system_score_gemma":0.0002651342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003815488,"about_ca_topic_score_gemma":0.001674543,"domain_scores_codex":[0.9964616,0.0009991712,0.001241843,0.0005845813,0.0004230556,0.0002897903],"domain_scores_gemma":[0.9968449,0.001244084,0.0005474843,0.0004687729,0.0007839255,0.0001108121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6965299,0.006326949,0.2908272,0.000561288,0.0005840099,3.175307e-7,0.002896294,0.000003162022,0.00001510676,0.00008893796,0.000009665447,0.00215715],"study_design_scores_gemma":[0.759816,0.01128898,0.2235641,0.0001929422,0.0004040205,6.41329e-7,0.002485494,0.0002031227,0.00005098179,0.001875822,0.00001037668,0.0001075392],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7266743,0.0008702241,0.00002892953,0.0001778172,0.00006588618,0.2720395,0.00006482786,0.00001114137,0.00006736018],"genre_scores_gemma":[0.8962001,0.00006566819,0.0002104339,0.000008130733,0.00008064629,0.1033712,0.00001866666,0.00001267923,0.00003249204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1695258,"threshold_uncertainty_score":0.724937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2342718423793489,"score_gpt":0.4543217834680711,"score_spread":0.2200499410887222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}