{"id":"W2886637264","doi":"10.1186/s40814-018-0327-z","title":"Study protocol: a randomized, double-blind, parallel, two-arm, placebo control trial investigating the feasibility and safety of immunoglobulin treatment in COPD patients for prevention of frequent recurrent exacerbations","year":2018,"lang":"en","type":"article","venue":"Pilot and Feasibility Studies","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Clinical Evaluative Sciences; Ottawa Public Health; Ottawa Hospital; University of Ottawa","funders":"Ottawa Hospital Research Institute; Grifols; CSL Behring","keywords":"Medicine; Exacerbation; COPD; Tolerability; Randomized controlled trial; Quality of life (healthcare); Adverse effect; Placebo; Randomization; Intensive care medicine; Clinical trial; Internal medicine; Physical therapy; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005359975,0.004414018,0.006332363,0.0009904238,0.0014622,0.002251613,0.002033141,0.005983701,0.02679364],"category_scores_gemma":[0.007359399,0.001494936,0.00233966,0.0007673498,0.002279433,0.001940173,0.0008123952,0.003947718,0.004082242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001282772,"about_ca_system_score_gemma":0.005539673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009734074,"about_ca_topic_score_gemma":0.00190888,"domain_scores_codex":[0.9957392,0.002231793,0.0004350719,0.0006379153,0.0004450616,0.0005110211],"domain_scores_gemma":[0.9968957,0.0007215804,0.0007319657,0.0002709868,0.0003942212,0.0009856892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9870903,0.004007057,0.0001644961,0.001399614,0.0003333228,0.00002272298,0.000025401,0.00009358576,0.0005098735,0.0001434384,0.0008396241,0.005370597],"study_design_scores_gemma":[0.9910891,0.007901537,0.0001910862,0.00004894539,0.0001167225,0.000005308344,0.00000349538,0.00006446432,0.00004727258,0.00005963591,0.0004673982,0.000005036065],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.2536543,0.007697023,0.003586523,0.002746995,0.00515295,0.7108357,0.006130842,0.0006012282,0.009594478],"genre_scores_gemma":[0.2571236,0.003247444,0.008552535,0.004073333,0.001720381,0.716671,0.001913808,0.00004057118,0.006657339],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02679364,"threshold_uncertainty_score":0.08963364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2342718423793489,"score_gpt":0.4543217834680711,"score_spread":0.2200499410887222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}