{"id":"W2886646081","doi":"10.1159/000492549","title":"Constitutive Activation of β-Catenin in Differentiated Osteoclasts Induces Bone Loss in Mice","year":2018,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Natural Science Foundation of China","keywords":"Osteoclast; Chemistry; Wnt signaling pathway; Tartrate-resistant acid phosphatase; Catenin; Osteoblast; Bone marrow; Bone resorption; Cell biology; In vitro; Endocrinology; Molecular biology; Internal medicine; Biology; Signal transduction; Biochemistry; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005810244,0.001100226,0.0007257292,0.001877337,0.000461362,0.0009577546,0.0007266897,0.00147591,0.004756075],"category_scores_gemma":[0.0002732026,0.0008566697,0.001018066,0.000620169,0.001053231,0.0004673325,0.000762567,0.002239847,0.001405708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007386646,"about_ca_system_score_gemma":0.000568622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006681787,"about_ca_topic_score_gemma":0.001400636,"domain_scores_codex":[0.9990517,0.00008716293,0.0001175915,0.0002755825,0.000287142,0.000180826],"domain_scores_gemma":[0.9991363,0.00007067133,0.0004384655,0.00005876722,0.00004805548,0.0002478883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002828041,0.0001233648,0.000490915,0.0000834793,0.00001479755,0.0002113561,0.00002601938,0.00005243502,0.9975,0.0001744527,0.00006594442,0.0009744723],"study_design_scores_gemma":[0.0005056352,0.002047719,0.02307847,0.0001574927,0.0001724657,0.004906047,0.0001942082,0.001535567,0.9589869,0.0005013655,0.007872788,0.00004133781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813364,0.004411093,0.007498557,0.0003268938,0.00007536475,0.0002004967,0.002991825,0.0005978026,0.002561574],"genre_scores_gemma":[0.9756708,0.00328706,0.005640008,0.0002860804,0.00003526168,0.0004085818,0.003309107,0.0002292766,0.01113376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004756075,"threshold_uncertainty_score":0.01591063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007671254531223508,"score_gpt":0.2205361461361836,"score_spread":0.2128648916049601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}