{"id":"W2886803370","doi":"10.1158/1538-7445.am2018-ct009","title":"Abstract CT009: Results of a dose- and regimen-finding Phase Ib study of HDM201 in combination with ribociclib in patients with locally advanced or metastatic liposarcoma","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Regimen; Neutropenia; Internal medicine; Liposarcoma; Adverse effect; Phases of clinical research; Gastroenterology; Oncology; Chemotherapy; Sarcoma; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008610472,0.0001728533,0.0005095165,0.0006060153,0.00005304526,0.00001065454,0.0001436641,0.00004123467,0.00003544415],"category_scores_gemma":[0.0001881823,0.0001182788,0.00001316579,0.001258158,0.0005054069,0.0002644907,0.00005810239,0.0003766726,8.981925e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003268991,"about_ca_system_score_gemma":0.0004500513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001182302,"about_ca_topic_score_gemma":0.004089195,"domain_scores_codex":[0.9975448,0.000158944,0.0005083592,0.0004336413,0.0009411976,0.0004130462],"domain_scores_gemma":[0.9981839,0.0002714308,0.0002433629,0.0003895447,0.0008000718,0.0001116636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3616083,0.01261246,0.3780722,0.001022867,0.0003790984,0.0001894256,0.02126028,0.0001687428,0.01459433,0.00004698506,0.00002397062,0.2100213],"study_design_scores_gemma":[0.1335966,0.03036784,0.8189775,0.002350051,0.00003610394,0.000004683766,0.005159215,0.000067016,0.009114835,0.00008344703,0.00006378146,0.0001789354],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997083,0.0002228964,0.00002388212,0.0001549385,0.00002033431,0.002341782,0.00003422593,0.0000111808,0.0001077614],"genre_scores_gemma":[0.998861,0.00003722354,0.0007330003,0.00001439599,0.00001884821,0.0002112171,0.00001326338,0.00003685063,0.00007425307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4409053,"threshold_uncertainty_score":0.4823268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07042861192374962,"score_gpt":0.4342547883557902,"score_spread":0.3638261764320406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}