{"id":"W2886803370","doi":"10.1158/1538-7445.am2018-ct009","title":"Abstract CT009: Results of a dose- and regimen-finding Phase Ib study of HDM201 in combination with ribociclib in patients with locally advanced or metastatic liposarcoma","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Regimen; Neutropenia; Internal medicine; Liposarcoma; Adverse effect; Phases of clinical research; Gastroenterology; Oncology; Chemotherapy; Sarcoma; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001261693,0.001369617,0.002037079,0.0005179025,0.0004546458,0.0008841505,0.0008909267,0.001010038,0.003861555],"category_scores_gemma":[0.000747723,0.0004584101,0.001264372,0.0005655778,0.001019399,0.000765455,0.000396727,0.002675601,0.001248382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001129386,"about_ca_system_score_gemma":0.001821614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001620709,"about_ca_topic_score_gemma":0.003721017,"domain_scores_codex":[0.9995633,0.0002140059,0.00003031171,0.00006548641,0.00004124063,0.00008573149],"domain_scores_gemma":[0.9994003,0.0001042318,0.00009981256,0.00005622939,0.0000421473,0.0002973151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6482158,0.121685,0.01241455,0.0007662912,0.001449838,0.0006787384,0.0003965769,0.004785469,0.1125978,0.0002908469,0.003973274,0.092746],"study_design_scores_gemma":[0.2642849,0.7042167,0.01807407,0.00003671541,0.0006841904,0.0004715748,0.00008690524,0.001380112,0.007947026,0.0001339918,0.002648116,0.00003568156],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922741,0.001087087,0.0005500108,0.000308972,0.00005673737,0.002098157,0.001449412,0.0000850234,0.002090335],"genre_scores_gemma":[0.9874189,0.001137216,0.001903899,0.0005023601,0.0001546213,0.00198076,0.004103684,0.00003792322,0.002760526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003861555,"threshold_uncertainty_score":0.01291817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07042861192374962,"score_gpt":0.4342547883557902,"score_spread":0.3638261764320406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}