{"id":"W2886808119","doi":"10.1101/381160","title":"Mitochondrial RNA capping: highly efficient 5’-RNA capping with NAD <sup>+</sup> and NADH by yeast and human mitochondrial RNA polymerase","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Genetics","funders":"National Institutes of Health; Children's Hospital of Philadelphia; American Heart Association","keywords":"NAD+ kinase; Biochemistry; RNA; Biology; Transcription (linguistics); Nicotinamide adenine dinucleotide; Polymerase; Molecular biology; Chemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005341232,0.0004357549,0.000228017,0.0001417545,0.0001713819,0.0004826479,0.0002391625,0.0002413087,0.0008858833],"category_scores_gemma":[0.0004504992,0.0002033672,0.0003045927,0.0001442707,0.0002519137,0.0002096957,0.0002913823,0.0004415683,0.0006238022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002842921,"about_ca_system_score_gemma":0.0001813396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003684361,"about_ca_topic_score_gemma":0.0006130367,"domain_scores_codex":[0.9996954,0.00007339926,0.00002109277,0.00009996208,0.00006946752,0.00004064304],"domain_scores_gemma":[0.9998299,0.00004206023,0.00003614246,0.00003451663,0.0000333319,0.00002396403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000840011,0.00001130627,0.000165394,0.00005069856,0.000005469036,0.00003881485,0.00002291053,0.0001958686,0.9940707,0.0002522169,0.0001432428,0.004959361],"study_design_scores_gemma":[0.000003894574,0.00003165344,0.0003083757,0.00000266034,0.000002778272,0.00004928518,0.000004734471,0.0007558409,0.9971628,0.00003811847,0.001637363,0.000002595321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.86304,0.004761212,0.1237773,0.0003350932,0.0002204038,0.000164452,0.001192617,0.001305647,0.005203397],"genre_scores_gemma":[0.9390058,0.0008400475,0.05455986,0.0001146721,0.00003666127,0.00006416225,0.002127075,0.0001727101,0.003079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008858833,"threshold_uncertainty_score":0.002963543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007408901810537809,"score_gpt":0.2028931734879763,"score_spread":0.1954842716774385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}