{"id":"W2886821920","doi":"10.1016/j.ebiom.2018.08.011","title":"A novel mechanism of SRRM4 in promoting neuroendocrine prostate cancer development via a pluripotency gene network","year":2018,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Health Canada; China Scholarship Council; National Natural Science Foundation of China","keywords":"DU145; Biology; SOX2; Cellular differentiation; Transcriptome; Cancer research; Cell biology; Transdifferentiation; Stem cell; Carcinogenesis; Neuroendocrine differentiation; Cancer cell; Gene expression; Gene; Embryonic stem cell; Genetics; Cancer; Prostate cancer; LNCaP","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003519826,0.0002398285,0.0005175858,0.0003166188,0.00008829975,0.000005785306,0.0001264719,0.00004267524,0.0002291723],"category_scores_gemma":[0.00005077548,0.0001722135,0.00004684427,0.000985623,0.0002430953,0.00005887855,0.0001215751,0.0002255442,0.00001632305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002301832,"about_ca_system_score_gemma":0.0004940324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004105659,"about_ca_topic_score_gemma":0.000162839,"domain_scores_codex":[0.9977075,0.00002890388,0.0005906089,0.0004254797,0.0005385343,0.0007089407],"domain_scores_gemma":[0.9990616,0.00003077671,0.0001567597,0.0002769317,0.0002471665,0.0002267129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002309594,0.001266945,0.03578737,0.001030212,0.0003997114,0.001074551,0.006958158,0.000007451139,0.8212846,0.0001435801,0.0009095315,0.1288283],"study_design_scores_gemma":[0.03082646,0.006226406,0.09991133,0.004413753,0.0002507387,0.0007626637,0.0002771126,0.004685645,0.8349487,0.0009494823,0.01607173,0.0006759308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861852,0.002705432,0.001968391,0.00570885,0.0006521897,0.002023623,0.00001689795,0.0000842866,0.0006551225],"genre_scores_gemma":[0.9901829,0.0003662937,0.006044765,0.0003666472,0.0008041532,0.0002047738,0.00007870416,0.00004643761,0.001905376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1281524,"threshold_uncertainty_score":0.7022665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02360354005568647,"score_gpt":0.3097456536074462,"score_spread":0.2861421135517597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}