{"id":"W2886878286","doi":"10.1089/hum.2018.106","title":"Combinatorial <i>Prg4</i> and <i>Il-1ra</i> Gene Therapy Protects Against Hyperalgesia and Cartilage Degeneration in Post-Traumatic Osteoarthritis","year":2018,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; Intellectual and Developmental Disabilities Research Center; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute","keywords":"Osteoarthritis; Synovitis; Medicine; Cartilage; Inflammation; Genetic enhancement; Receptor antagonist; Immunology; Bioinformatics; Arthritis; Antagonist; Pathology; Receptor; Internal medicine; Biology; Gene; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002564867,0.0003740288,0.0005016566,0.0001766757,0.0003188804,0.00009799757,0.00007985211,0.0001939822,0.00006017859],"category_scores_gemma":[0.000008700532,0.0003368534,0.00007042139,0.0001629202,0.000194402,0.0001791142,0.00002928154,0.0001697981,0.0000165795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000542159,"about_ca_system_score_gemma":0.0000718001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003376215,"about_ca_topic_score_gemma":0.0002763954,"domain_scores_codex":[0.9982149,0.0001412524,0.0003943806,0.0005273084,0.0002888895,0.000433239],"domain_scores_gemma":[0.9991621,0.00002328437,0.0001055194,0.00037291,0.0001422561,0.000193911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005876975,0.0002275151,0.000621725,0.00001560627,0.00001809327,0.00009416146,0.002143314,1.323297e-7,0.929261,0.0003861507,0.00002791047,0.06661664],"study_design_scores_gemma":[0.0220679,0.01235351,0.001753532,0.0001062361,0.00001981869,0.0001646739,0.0001450953,0.000005479405,0.9611526,0.0009828211,0.0008976668,0.0003507064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891399,0.007449043,0.000005752443,0.0002039047,0.000320813,0.002192643,0.00002065396,0.000108068,0.0005591797],"genre_scores_gemma":[0.9942552,0.002544539,0.000516791,0.001392437,0.0007072889,0.0002410793,0.0001458371,0.0000774916,0.0001193505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06626593,"threshold_uncertainty_score":0.9999083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01995496895304505,"score_gpt":0.2526728415980051,"score_spread":0.23271787264496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}