{"id":"W2886878286","doi":"10.1089/hum.2018.106","title":"Combinatorial <i>Prg4</i> and <i>Il-1ra</i> Gene Therapy Protects Against Hyperalgesia and Cartilage Degeneration in Post-Traumatic Osteoarthritis","year":2018,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; Intellectual and Developmental Disabilities Research Center; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute","keywords":"Osteoarthritis; Synovitis; Medicine; Cartilage; Inflammation; Genetic enhancement; Receptor antagonist; Immunology; Bioinformatics; Arthritis; Antagonist; Pathology; Receptor; Internal medicine; Biology; Gene; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001357094,0.0004106796,0.0003199336,0.0003447186,0.0001039996,0.0003091346,0.0002797217,0.0003302821,0.0008724316],"category_scores_gemma":[0.00007628747,0.000114106,0.0002881413,0.00018664,0.0003457781,0.0001886528,0.0001568269,0.0004505915,0.0002348743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002445334,"about_ca_system_score_gemma":0.0002464604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004748942,"about_ca_topic_score_gemma":0.0007561885,"domain_scores_codex":[0.9998531,0.00002023239,0.00001154019,0.00003224247,0.00003918383,0.00004361574],"domain_scores_gemma":[0.9999387,0.000007391512,0.00002280625,0.000007974634,0.000005315313,0.00001775998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000223841,0.0001448618,0.0001070491,0.00006472858,0.00001176197,0.00003130723,0.000009022038,0.0003257902,0.9954184,0.0001736718,0.00005138331,0.003438201],"study_design_scores_gemma":[0.0000598705,0.001615238,0.001553466,0.000007158706,0.00004310785,0.0001507175,0.0000151241,0.001082942,0.993503,0.00005164562,0.001910588,0.000007103275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881653,0.003010296,0.006998968,0.00009849445,0.00005794361,0.00007560688,0.0002066619,0.0001314329,0.0012554],"genre_scores_gemma":[0.99228,0.001540487,0.004283376,0.00004889045,0.00001434163,0.00007297323,0.0002111039,0.00001442547,0.0015344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008724316,"threshold_uncertainty_score":0.002918601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01995496895304505,"score_gpt":0.2526728415980051,"score_spread":0.23271787264496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}