{"id":"W2886881211","doi":"10.1016/j.ajpath.2018.06.024","title":"DNA Methylation Reduces the Yes-Associated Protein 1/WW Domain Containing Transcription Regulator 1 Pathway and Prevents Pathologic Remodeling during Bladder Obstruction by Limiting Expression of BDNF","year":2018,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Heart and Stroke Foundation; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Kingston General Hospital; Queen's University; Hospital for Sick Children; SickKids Foundation; Toronto General Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Regulator; Limiting; Methylation; Transcription (linguistics); DNA methylation; Biology; WW domain; Cell biology; DNA; Genetics; Cancer research; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000526275,0.0001290876,0.0002175769,0.00004966395,0.000147318,0.00001114257,0.0001176848,0.00008604456,0.000002933269],"category_scores_gemma":[0.0001186801,0.00009999907,0.00006674448,0.00009664628,0.0003177977,0.00001175486,0.00004666,0.0001253116,1.488497e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001552073,"about_ca_system_score_gemma":0.00003673423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002285251,"about_ca_topic_score_gemma":0.000002179569,"domain_scores_codex":[0.9986342,0.0003926954,0.0004445001,0.0002115592,0.0001375544,0.0001794872],"domain_scores_gemma":[0.9989275,0.00001532061,0.0007634019,0.0001108748,0.0001387641,0.0000441597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001956176,0.00003203363,0.0005751861,0.000005079086,0.00002142974,0.000004730413,0.0007324347,0.000021084,0.9877074,0.000002919167,0.000006056944,0.01069607],"study_design_scores_gemma":[0.0006060094,0.001511862,0.02172477,0.00006090814,0.00001958805,0.000178247,0.002214707,0.00002309245,0.9732478,0.0002617752,0.00003856629,0.0001126432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981961,0.0003880698,0.00105713,0.00008666854,0.00009024961,0.0001459951,0.00000716606,0.000003991663,0.00002465864],"genre_scores_gemma":[0.9969864,0.0001533893,0.002723307,0.0000453207,0.00004450199,0.000005776566,0.00001180449,0.00001663042,0.0000128373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02114958,"threshold_uncertainty_score":0.4077844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008415471126698104,"score_gpt":0.2254904580885269,"score_spread":0.2170749869618288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}