{"id":"W2886881211","doi":"10.1016/j.ajpath.2018.06.024","title":"DNA Methylation Reduces the Yes-Associated Protein 1/WW Domain Containing Transcription Regulator 1 Pathway and Prevents Pathologic Remodeling during Bladder Obstruction by Limiting Expression of BDNF","year":2018,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Heart and Stroke Foundation; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Kingston General Hospital; Queen's University; Hospital for Sick Children; SickKids Foundation; Toronto General Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Regulator; Limiting; Methylation; Transcription (linguistics); DNA methylation; Biology; WW domain; Cell biology; DNA; Genetics; Cancer research; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001452807,0.0002579732,0.0003144703,0.0001829042,0.0002065245,0.0002316367,0.000377743,0.0003667617,0.002323489],"category_scores_gemma":[0.0002063485,0.0002379368,0.0002591207,0.00007499784,0.0004097836,0.0002050867,0.0002476419,0.0008585774,0.0003111007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003008839,"about_ca_system_score_gemma":0.000369013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001081259,"about_ca_topic_score_gemma":0.002508841,"domain_scores_codex":[0.9998343,0.00002062417,0.00001292679,0.00003634029,0.0000262342,0.00006965689],"domain_scores_gemma":[0.9998154,0.00001456521,0.00006610184,0.00001741446,0.0000143026,0.00007217563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007034534,0.00007094384,0.0003091035,0.00003479102,0.00001336775,0.00003369445,0.00001813767,0.00006159219,0.9967887,0.0001085412,0.00007549952,0.001782259],"study_design_scores_gemma":[0.0001059179,0.001130268,0.01228793,0.00001295494,0.00007436874,0.0002599742,0.00009498808,0.0009935788,0.9831827,0.0001572442,0.001689052,0.00001103579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975874,0.0007189752,0.0008919092,0.0001345838,0.0000470643,0.00001109748,0.000109665,0.00007911352,0.0004201627],"genre_scores_gemma":[0.9977285,0.0002678179,0.0003448136,0.00003567097,0.000007119975,0.00001316807,0.0001153037,0.00001597853,0.001471539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002323489,"threshold_uncertainty_score":0.007772803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008415471126698104,"score_gpt":0.2254904580885269,"score_spread":0.2170749869618288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}