{"id":"W2886916674","doi":"10.1002/1873-3468.13209","title":"Solution structures of the <scp>SH</scp>3 domains from Shank scaffold proteins and their interactions with Cav1.3 calcium channels","year":2018,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Scaffold protein; Postsynaptic density; Chemistry; Cav1.2; Protein–protein interaction; Plasma protein binding; Binding site; Biophysics; Postsynaptic potential; Cell biology; Calcium channel; Calcium; Biochemistry; Biology; Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001769807,0.0003930765,0.0003328266,0.0002073537,0.0004530024,0.000508767,0.0007303102,0.0005144469,0.001596626],"category_scores_gemma":[0.0006108604,0.0002580443,0.0002526071,0.0004668732,0.0003279049,0.0004425953,0.000248456,0.001401109,0.0002522574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008960903,"about_ca_system_score_gemma":0.0006659749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003734265,"about_ca_topic_score_gemma":0.004118803,"domain_scores_codex":[0.9998964,0.00001442114,0.00000617048,0.00001610001,0.00003841856,0.000028504],"domain_scores_gemma":[0.9997653,0.00008539676,0.00005443202,0.00001179176,0.00003726143,0.00004572097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002319499,0.0004789871,0.007250902,0.0008844606,0.0003411516,0.001932267,0.001008924,0.06127052,0.8837647,0.01231993,0.009333897,0.01909484],"study_design_scores_gemma":[0.001384108,0.001023333,0.0477118,0.000206383,0.0003984416,0.001387426,0.00195714,0.4761467,0.4319891,0.01235014,0.02513541,0.0003100037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924891,0.001202537,0.002680187,0.0004504873,0.00003293219,0.00001384581,0.0008021466,0.00007871941,0.002250125],"genre_scores_gemma":[0.9907065,0.001246391,0.003649407,0.0001247872,0.00002028609,0.0000338817,0.003547727,0.00003450656,0.0006365585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003734265,"threshold_uncertainty_score":0.00742507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009292412697443197,"score_gpt":0.2079247350441179,"score_spread":0.1986323223466747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}