{"id":"W2886927415","doi":"10.1016/j.mito.2018.07.007","title":"Toxic medications in Leber's hereditary optic neuropathy","year":2018,"lang":"en","type":"review","venue":"Mitochondrion","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"","keywords":"Leber's hereditary optic neuropathy; Optic neuropathy; Medicine; Reactive oxygen species; Pathophysiology; Population; Bioinformatics; Neuroscience; Genetics; Biology; Pathology; Optic nerve; Ophthalmology; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004079694,0.0008892255,0.00118352,0.002245435,0.0002481823,0.0008425605,0.0007719966,0.001094455,0.002155185],"category_scores_gemma":[0.0007569145,0.0002373016,0.0003661814,0.001879712,0.0004960235,0.001046201,0.0007438184,0.001533443,0.0008393735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004072719,"about_ca_system_score_gemma":0.0007354162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008940349,"about_ca_topic_score_gemma":0.001799042,"domain_scores_codex":[0.9998384,0.0000251743,0.00003807457,0.00002349423,0.00006150555,0.00001340421],"domain_scores_gemma":[0.9996819,0.0001544827,0.00007192716,0.000009642351,0.00005523426,0.00002674275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007759111,0.00005146666,0.0003189696,0.01172125,0.0000814485,0.001335315,0.00005585683,0.0002936102,0.001078401,0.00250736,0.02643922,0.9560396],"study_design_scores_gemma":[0.00004512193,0.00007786785,0.001383944,0.00529997,0.0003198875,0.01027092,0.00009997439,0.0001820555,0.0007684952,0.003124909,0.9783991,0.0000277319],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001360009,0.9986709,0.0001569165,0.0002010602,0.0002052636,0.000002388141,0.00001193306,0.000005786599,0.0006097729],"genre_scores_gemma":[0.001375265,0.9969521,0.0002947244,0.0002496087,0.0004781965,0.00000448068,0.00002866466,0.000001967826,0.00061497],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002245435,"threshold_uncertainty_score":0.007209837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02600331579088448,"score_gpt":0.3017411386464945,"score_spread":0.27573782285561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}