{"id":"W2886929323","doi":"10.1016/j.ygeno.2018.08.001","title":"The tricarboxylic acid cycle, cell wall integrity pathway, cytokinesis and intracellular pH homeostasis are involved in the sensitivity of Candida albicans cells to high levels of extracellular calcium","year":2018,"lang":"en","type":"article","venue":"Genomics","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University","funders":"National Natural Science Foundation of China","keywords":"Biology; Candida albicans; Calcium; Extracellular; Calcineurin; Cytokinesis; Cell biology; Calcium in biology; Homeostasis; Calcium metabolism; Biochemistry; Antifungal drug; Intracellular; Cell; Microbiology; Cell division; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000140768,0.0004707297,0.0003218223,0.0005424825,0.0003903852,0.0007795967,0.0003191613,0.0004011004,0.001069565],"category_scores_gemma":[0.0001960484,0.0002348378,0.0002667567,0.0004003795,0.0003245485,0.0003277783,0.000376373,0.0005123712,0.0002005411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000609183,"about_ca_system_score_gemma":0.0005263461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002685081,"about_ca_topic_score_gemma":0.003009742,"domain_scores_codex":[0.9998288,0.00001872659,0.00001311115,0.00004501873,0.00005565818,0.00003860528],"domain_scores_gemma":[0.9998295,0.00001812024,0.00006813031,0.00001341742,0.00002917496,0.00004149024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004998869,0.00002671106,0.001445049,0.00006928527,0.00001405116,0.00009118301,0.00002803712,0.0001633058,0.9930378,0.0004198525,0.0001010581,0.004103774],"study_design_scores_gemma":[0.0000546738,0.0002147576,0.118417,0.0000266482,0.00009311359,0.0008195759,0.0001883912,0.003129602,0.8719247,0.000952388,0.00414274,0.00003644948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986483,0.004774322,0.004392188,0.0004673988,0.00003939744,0.00004548581,0.001482564,0.0001965618,0.002119134],"genre_scores_gemma":[0.9941415,0.001039762,0.002368973,0.00007358663,0.000009193027,0.00001634871,0.0008502292,0.00002307196,0.001477291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002685081,"threshold_uncertainty_score":0.005338907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02648705173842048,"score_gpt":0.2525626140926355,"score_spread":0.2260755623542151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}