{"id":"W2886929323","doi":"10.1016/j.ygeno.2018.08.001","title":"The tricarboxylic acid cycle, cell wall integrity pathway, cytokinesis and intracellular pH homeostasis are involved in the sensitivity of Candida albicans cells to high levels of extracellular calcium","year":2018,"lang":"en","type":"article","venue":"Genomics","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University","funders":"National Natural Science Foundation of China","keywords":"Biology; Candida albicans; Calcium; Extracellular; Calcineurin; Cytokinesis; Cell biology; Calcium in biology; Homeostasis; Calcium metabolism; Biochemistry; Antifungal drug; Intracellular; Cell; Microbiology; Cell division; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002163867,0.0002591941,0.0006430257,0.0001092931,0.000146639,0.00002411267,0.0002466598,0.0001872514,0.00002087404],"category_scores_gemma":[0.0003093822,0.0001673559,0.0001401935,0.000464016,0.0005357959,0.00004843346,0.0001192419,0.0004134156,0.000006441489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001640703,"about_ca_system_score_gemma":0.0002487283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002584949,"about_ca_topic_score_gemma":0.006380059,"domain_scores_codex":[0.9978265,0.000319586,0.0006336953,0.0004340847,0.0003622847,0.0004238512],"domain_scores_gemma":[0.99784,0.0005564474,0.0002881733,0.0008648984,0.0002964153,0.0001540659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006584995,0.0002727538,0.0249943,0.0001832342,0.00004554178,0.00004906677,0.002973584,0.000007430064,0.9650125,0.0001156552,0.0001273755,0.005560059],"study_design_scores_gemma":[0.0008808136,0.0003467685,0.2446493,0.00006931765,0.0001128389,0.000005369727,0.004071567,0.0004212109,0.7474589,0.0001900584,0.00159088,0.0002029531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951316,0.001551154,0.001004446,0.001074225,0.00009963895,0.0007562229,0.0002618624,0.00001251939,0.0001083572],"genre_scores_gemma":[0.9985395,0.0003145107,0.0006114433,0.0002845419,0.0001056972,0.0000110925,0.000008476834,0.0000260284,0.00009869327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.219655,"threshold_uncertainty_score":0.6824577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02648705173842048,"score_gpt":0.2525626140926355,"score_spread":0.2260755623542151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}