{"id":"W2886930165","doi":"10.1172/jci121960","title":"Circulating and intrahepatic antiviral B cells are defective in hepatitis B","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":326,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; National Institute for Health and Care Research; Gilead Sciences; Wellcome Trust; F. Hoffmann-La Roche; Roche","keywords":"HBsAg; Hepatitis B virus; Antibody; Immunology; Hepatitis B; Antigen; Biology; Virology; B cell; Medicine; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001556523,0.0001048615,0.0005909334,0.0001492018,0.00005501505,0.00001818235,0.0000426574,0.0001202528,0.00001300167],"category_scores_gemma":[0.005486742,0.00008732834,0.0001006178,0.0002146819,0.000472482,0.0002223268,0.00003270562,0.0004367829,0.00001302662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006058034,"about_ca_system_score_gemma":0.0001437326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002557303,"about_ca_topic_score_gemma":0.00109262,"domain_scores_codex":[0.997887,0.00026721,0.001275838,0.0001511755,0.0002708077,0.0001480067],"domain_scores_gemma":[0.9978036,0.000633526,0.0008699815,0.00009428548,0.0004385982,0.0001599895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005781823,0.00005691344,0.988928,0.00004351352,0.00005059468,0.0001108157,0.0006356874,0.000001201508,0.001959947,0.00004414757,0.0002903831,0.007820957],"study_design_scores_gemma":[0.001214866,0.0009666527,0.9893174,0.0007795283,0.00008362821,0.0000609587,0.00006478053,0.001552366,0.003099798,0.002684653,0.00009476828,0.00008056422],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978187,0.0001129263,0.0001892723,0.000875926,0.0004283348,0.0001529401,0.000001736158,0.000008794363,0.0004113881],"genre_scores_gemma":[0.9938402,0.0003440232,0.004017639,0.0009131196,0.0008548931,0.000001684698,7.801182e-7,0.00001216734,0.00001549821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007740393,"threshold_uncertainty_score":0.6568539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.080721254435213,"score_gpt":0.3812247071006864,"score_spread":0.3005034526654734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}