{"id":"W2886930165","doi":"10.1172/jci121960","title":"Circulating and intrahepatic antiviral B cells are defective in hepatitis B","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":326,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; National Institute for Health and Care Research; Gilead Sciences; Wellcome Trust; F. Hoffmann-La Roche; Roche","keywords":"HBsAg; Hepatitis B virus; Antibody; Immunology; Hepatitis B; Antigen; Biology; Virology; B cell; Medicine; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002152782,0.00023625,0.0002833261,0.0004159297,0.0001792834,0.0003326702,0.0001529037,0.0003362454,0.002928224],"category_scores_gemma":[0.0002526071,0.0001831246,0.0001223524,0.0001637983,0.0003515167,0.0002307939,0.000220998,0.0005665184,0.0008117023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00012499,"about_ca_system_score_gemma":0.0001010162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000205306,"about_ca_topic_score_gemma":0.0001660556,"domain_scores_codex":[0.9998537,0.00002694472,0.00001707448,0.00003450646,0.00003099062,0.00003678459],"domain_scores_gemma":[0.9998543,0.00002350218,0.00002312043,0.00002679174,0.00001296608,0.00005923194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007334435,0.0001822435,0.004735596,0.00007015392,0.0000101006,0.0004018758,0.00008052412,0.00004016387,0.9868791,0.000255657,0.00009473322,0.006516442],"study_design_scores_gemma":[0.0004900887,0.007105902,0.181156,0.0000527382,0.0001152299,0.0209802,0.0005509889,0.00158837,0.7712263,0.0009919277,0.01571707,0.00002512813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977992,0.0008004885,0.0004270294,0.00004121751,0.00001188428,0.0000145709,0.0001365623,0.00004807018,0.0007208805],"genre_scores_gemma":[0.9978973,0.000211084,0.0003206148,0.00003483254,0.000009014728,0.00001720249,0.0002240443,0.00001561389,0.001270272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002928224,"threshold_uncertainty_score":0.009795904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.080721254435213,"score_gpt":0.3812247071006864,"score_spread":0.3005034526654734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}