{"id":"W2886939149","doi":"10.1038/s41388-018-0427-5","title":"Transcriptomic analysis of CIC and ATXN1L reveal a functional relationship exploited by cancer","year":2018,"lang":"en","type":"article","venue":"Oncogene","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; BC Cancer Agency; Provincial Health Services Authority; Government of Canada","keywords":"Biology; Derepression; Cancer research; Context (archaeology); Cell cycle; Transcriptome; Transcription factor; Cancer; Psychological repression; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001666135,0.0003117714,0.0002987034,0.0004769942,0.0003881323,0.0005292443,0.0002084931,0.0003917386,0.001996726],"category_scores_gemma":[0.0002941276,0.0001248439,0.0002684869,0.0004142697,0.0002751193,0.0003317543,0.00031914,0.0005231104,0.0005784045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005500952,"about_ca_system_score_gemma":0.0003822607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001086866,"about_ca_topic_score_gemma":0.001731362,"domain_scores_codex":[0.9998312,0.00001203421,0.00001360257,0.00006199726,0.00004380344,0.00003728496],"domain_scores_gemma":[0.9997328,0.0000460456,0.00009271639,0.00003481006,0.00004148931,0.00005219313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001161501,0.000009351743,0.003357657,0.00003798373,0.000007381509,0.0001824844,0.0000318537,0.00005353005,0.9945786,0.000237645,0.0001325914,0.001254692],"study_design_scores_gemma":[0.0000229883,0.0002591581,0.1801958,0.0000297177,0.00007247022,0.002263896,0.0004245276,0.003036603,0.7983359,0.0005663951,0.01477247,0.00002013449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899249,0.001630874,0.003939192,0.0002512005,0.00004936657,0.00002385516,0.002374012,0.00008162406,0.001724922],"genre_scores_gemma":[0.9836897,0.0005245346,0.003746984,0.0001978243,0.00002512125,0.00004573804,0.004615843,0.00005020583,0.007104006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001996726,"threshold_uncertainty_score":0.006679714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02046574577651834,"score_gpt":0.26889280583604,"score_spread":0.2484270600595217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}