{"id":"W2886996182","doi":"10.1016/j.ejphar.2018.08.016","title":"The novel peripherally active cannabinoid type 1 and serotonin type 3 receptor agonist AM9405 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome","year":2018,"lang":"en","type":"article","venue":"European Journal of Pharmacology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Uniwersytet Łódzki; Uniwersytet Medyczny w Lodzi; Fondation Brain Canada","keywords":"Irritable bowel syndrome; Serotonin; Agonist; Cannabinoid; Cannabinoid receptor; Motility; Abdominal pain; Medicine; Tegaserod; Serotonin Agonist; 5-HT receptor; Pharmacology; Internal medicine; Receptor; Endocrinology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000195906,0.0004021289,0.0007074933,0.0007756245,0.0003072514,0.0003790838,0.0005296306,0.0005974043,0.002584753],"category_scores_gemma":[0.0001536018,0.0002388205,0.0005231233,0.0003596173,0.0005308231,0.0004039728,0.0002232241,0.001436405,0.0005023322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003936987,"about_ca_system_score_gemma":0.0004283861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009391168,"about_ca_topic_score_gemma":0.003120704,"domain_scores_codex":[0.9997415,0.00003617116,0.00002498989,0.00003487262,0.00008372755,0.00007869106],"domain_scores_gemma":[0.9998795,0.00001224638,0.00003397194,0.00001147011,0.00001091928,0.00005190235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001948664,0.0004078627,0.000332168,0.0001279299,0.00005412096,0.0001326525,0.00002133448,0.0001324949,0.9867264,0.0002615743,0.0003770657,0.009477749],"study_design_scores_gemma":[0.0008153954,0.006725312,0.007461713,0.00003721718,0.0002063041,0.0006634652,0.00009751967,0.001602706,0.976267,0.000223501,0.005866881,0.00003309057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914997,0.002596906,0.002074205,0.0004756602,0.0001865945,0.00005789717,0.0007438935,0.00026269,0.002102341],"genre_scores_gemma":[0.9891026,0.002597671,0.003431404,0.0002321412,0.0000433504,0.00008284539,0.0008327608,0.00002657973,0.003650554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002584753,"threshold_uncertainty_score":0.008646846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02460488991796166,"score_gpt":0.2989156827744583,"score_spread":0.2743107928564967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}