{"id":"W2887030048","doi":"10.1038/s41467-018-05841-x","title":"LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Tokyo University of Agriculture; Genome British Columbia; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Natural Sciences and Engineering Research Council of Canada; Japan Agency for Medical Research and Development","keywords":"Retrotransposon; Biology; DNA methylation; Epigenetics; Genetics; Genome; Promoter; CpG site; Long terminal repeat; Epigenomics; Human genome; Transposable element; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001730974,0.0001527816,0.0001263392,0.0002072755,0.0001177554,0.0003044498,0.0001992097,0.0001630747,0.001926207],"category_scores_gemma":[0.0001993127,0.0001965772,0.000155802,0.0001207037,0.0001996153,0.0001548478,0.0003051059,0.0003580278,0.0004608927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001691759,"about_ca_system_score_gemma":0.0001303619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002414703,"about_ca_topic_score_gemma":0.0009332151,"domain_scores_codex":[0.9998395,0.00001706206,0.00001175405,0.00006118158,0.00004005905,0.00003036523],"domain_scores_gemma":[0.9998111,0.0000254824,0.0000799414,0.00003130434,0.00001736826,0.00003471332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002189124,0.000003797364,0.0005695017,0.00001024482,0.00000227052,0.00001605728,0.00001782108,0.00001031683,0.9979772,0.0001191361,0.00001272255,0.001239019],"study_design_scores_gemma":[0.00002356447,0.0002279937,0.02751693,0.00001405508,0.00003101156,0.0005445263,0.00009725003,0.0004784208,0.9655842,0.0002120485,0.005263663,0.000006323598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910042,0.0008881385,0.004917876,0.00006298099,0.00002168261,0.00001828694,0.0003795765,0.0001738221,0.002533358],"genre_scores_gemma":[0.9926119,0.0005637993,0.002585321,0.00004727668,0.00001088238,0.00001779594,0.0005389919,0.00007205754,0.00355183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001926207,"threshold_uncertainty_score":0.006443799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02401195459750413,"score_gpt":0.2885605114160327,"score_spread":0.2645485568185286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}