{"id":"W2887030048","doi":"10.1038/s41467-018-05841-x","title":"LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Tokyo University of Agriculture; Genome British Columbia; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Natural Sciences and Engineering Research Council of Canada; Japan Agency for Medical Research and Development","keywords":"Retrotransposon; Biology; DNA methylation; Epigenetics; Genetics; Genome; Promoter; CpG site; Long terminal repeat; Epigenomics; Human genome; Transposable element; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000273421,0.000116565,0.0001285243,0.0001274866,0.0001136509,0.00002525548,0.0003138582,0.0003249817,0.00001555099],"category_scores_gemma":[0.00006554852,0.0001239441,0.00002951822,0.000309923,0.0001779904,0.000008205925,0.00007122807,0.0003251349,0.000002238857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002710588,"about_ca_system_score_gemma":0.00002670441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000282567,"about_ca_topic_score_gemma":0.01509841,"domain_scores_codex":[0.9991485,0.0001589321,0.0001879562,0.000246081,0.00008590249,0.0001725774],"domain_scores_gemma":[0.9990116,0.00005435681,0.00005198953,0.0007388932,0.0001025271,0.00004059094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003423151,0.0000684498,0.01439476,0.00000569174,0.000009479936,3.808283e-7,0.0005734497,0.000005639585,0.980601,0.001714988,0.00009733547,0.002494589],"study_design_scores_gemma":[0.000757692,0.0002057132,0.2480256,0.0000396042,0.00001075818,0.000001290019,0.0002957335,0.0001889681,0.5528242,0.0007283541,0.1966695,0.0002525485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9537593,0.03765464,0.0003663579,0.003158646,0.00009911156,0.000332245,0.00003764487,0.00001368433,0.004578368],"genre_scores_gemma":[0.9820948,0.01305884,0.004229126,0.00009382799,0.0000954003,0.00003617564,0.0002536152,0.00001597302,0.0001222012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4277768,"threshold_uncertainty_score":0.8425267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02401195459750413,"score_gpt":0.2885605114160327,"score_spread":0.2645485568185286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}