{"id":"W2887042787","doi":"10.1158/1538-7445.am2018-1642","title":"Abstract 1642: Alectinib in treatment-naïve anaplastic lymphoma kinase-positive (<i>ALK</i>+) metastatic non-small-cell lung cancer (mNSCLC): Systematic literature review (SLR) and network meta-analysis (NMA)","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System","funders":"","keywords":"Alectinib; Medicine; Crizotinib; Ceritinib; Internal medicine; Oncology; Anaplastic lymphoma kinase; Lung cancer; Pemetrexed; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01347148,0.001854186,0.01173999,0.007394288,0.0005772645,0.003095324,0.001444008,0.001809023,0.006401704],"category_scores_gemma":[0.03113578,0.0008159691,0.02356137,0.007214144,0.0007025714,0.001848759,0.001444516,0.00149451,0.0006609512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002767397,"about_ca_system_score_gemma":0.004268283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006891589,"about_ca_topic_score_gemma":0.01852786,"domain_scores_codex":[0.9892436,0.005013371,0.003305327,0.00100735,0.001122633,0.0003076546],"domain_scores_gemma":[0.9817121,0.01202552,0.003987194,0.000486664,0.001545889,0.0002426796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001856454,0.00002304258,0.002319463,0.697167,0.2861247,0.0001143695,0.00008393429,0.0002871132,0.0004359898,0.0001846383,0.001806143,0.009597114],"study_design_scores_gemma":[0.00207179,0.0003270548,0.00538724,0.1043743,0.8815904,0.0001584871,0.00007863266,0.0002354428,0.0002117384,0.000388505,0.005144596,0.00003175387],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.009348998,0.9816307,0.0008702137,0.0006589699,0.0004356028,0.002157539,0.003601481,0.00007220908,0.001224295],"genre_scores_gemma":[0.258031,0.7225402,0.004016766,0.003078425,0.0005601659,0.006106848,0.004044821,0.00008069777,0.001540953],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01347148,"threshold_uncertainty_score":0.07124478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07856360242995693,"score_gpt":0.435012635975324,"score_spread":0.3564490335453671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}