{"id":"W2887053618","doi":"10.1111/bph.14472","title":"Efficacy of treprostinil in the SU5416‐hypoxia model of severe pulmonary arterial hypertension: haemodynamic benefits are not associated with improvements in arterial remodelling","year":2018,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; United Therapeutics Corporation","keywords":"Treprostinil; Right ventricular hypertrophy; Medicine; Pulmonary hypertension; Hemodynamics; Cardiology; Internal medicine; Ventricular pressure; Hypoxia (environmental); Muscle hypertrophy; Blood pressure; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003222776,0.0007112984,0.001096642,0.0003271745,0.0002124844,0.0003191857,0.0004197947,0.0005328049,0.001744125],"category_scores_gemma":[0.0001740793,0.0002407039,0.0004797361,0.000174686,0.000632179,0.0005645162,0.0002085297,0.001537102,0.0003614796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002433806,"about_ca_system_score_gemma":0.0004087468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000621716,"about_ca_topic_score_gemma":0.001134016,"domain_scores_codex":[0.9997774,0.00003774442,0.00002749146,0.00003795993,0.00004128103,0.00007815614],"domain_scores_gemma":[0.9995433,0.00003820105,0.0001411691,0.00004042515,0.00002572313,0.0002111997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007148711,0.001172981,0.0003288553,0.0001232876,0.0000254065,0.000119929,0.00002913248,0.0001566855,0.9866008,0.00006334437,0.000116713,0.004114223],"study_design_scores_gemma":[0.0009685469,0.0454089,0.007495572,0.00002467013,0.00008282753,0.0004000732,0.00008510891,0.001007784,0.9428986,0.00005064454,0.001556513,0.0000207319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997853,0.0006889937,0.0004426001,0.0001320166,0.00005925556,0.00005888314,0.0002679584,0.00005225262,0.0004450695],"genre_scores_gemma":[0.993626,0.001018499,0.001424756,0.0001016151,0.00005586507,0.0001710127,0.0005401235,0.00002366699,0.003038502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001744125,"threshold_uncertainty_score":0.005834639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04400236492971423,"score_gpt":0.2954277495767648,"score_spread":0.2514253846470506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}