{"id":"W2887071657","doi":"10.1161/atvbaha.118.310792","title":"Estrogen Inhibits LDL (Low-Density Lipoprotein) Transcytosis by Human Coronary Artery Endothelial Cells via GPER (G-Protein–Coupled Estrogen Receptor) and SR-BI (Scavenger Receptor Class B Type 1)","year":2018,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Scavenger receptor; Transcytosis; GPER; Estrogen; Estrogen receptor; Internal medicine; Endocrinology; Chemistry; Lipoprotein; LDL receptor; Receptor; Biology; Medicine; Cholesterol; Endocytosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002263152,0.0002488239,0.0002976444,0.0001196768,0.0001434083,0.0001942633,0.0001117217,0.000207934,0.001108604],"category_scores_gemma":[0.0001158218,0.0001193914,0.0002822942,0.0001254628,0.0001326112,0.00009834827,0.0001540515,0.0003228056,0.0003411002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002039556,"about_ca_system_score_gemma":0.0002133419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007622285,"about_ca_topic_score_gemma":0.001179895,"domain_scores_codex":[0.9998062,0.00004323279,0.00001694674,0.00003963361,0.00004651623,0.00004747052],"domain_scores_gemma":[0.9999563,0.00001183878,0.00001031051,0.000005725867,0.000007095664,0.00000880703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003317836,0.00006567509,0.0002387324,0.00007979667,0.00001479168,0.00006407619,0.00002835949,0.00002887752,0.9962817,0.00006304207,0.0001267609,0.002676335],"study_design_scores_gemma":[0.0001477556,0.001362447,0.01452336,0.00001376019,0.00005259137,0.000303384,0.00003440091,0.0008360164,0.9769751,0.00004551369,0.005699212,0.000006342251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872971,0.008361379,0.001814405,0.0001981684,0.00006644802,0.00003351467,0.0002999156,0.00008287694,0.001846271],"genre_scores_gemma":[0.9871678,0.004209166,0.002398392,0.0001641332,0.00003279188,0.00007998048,0.0006353651,0.00001751959,0.005294853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001108604,"threshold_uncertainty_score":0.00370872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003697592103563,"score_gpt":0.2309684249361005,"score_spread":0.2209314490150648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}