{"id":"W2887072002","doi":"10.1016/j.celrep.2018.07.023","title":"Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; European Research Council; Medical Research Council; Medical Research Council Canada; Gottfried und Julia Bangerter-Rhyner-Stiftung; Associazione Italiana per la Ricerca sul Cancro; Seventh Framework Programme; Ministero dell’Istruzione, dell’Università e della Ricerca; Novartis Stiftung für Medizinisch-Biologische Forschung; Alzheimer's Society; Universitätsspital Basel; Universität Basel; Alzheimer’s Research UK; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis Foundation; Mach-Gaensslen Foundation of Canada; Desert Research Institute","keywords":"Mitochondrion; Cell biology; Tauopathy; Biology; Neuroscience; Neuron; Mitochondrial fission; Organelle; Cytokine; Mitophagy; Neurodegeneration; Apoptosis; Disease; Immunology; Medicine; Pathology; Autophagy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002361319,0.0002623745,0.000157069,0.0001009944,0.0002195544,0.000107934,0.0002857353,0.0002163369,0.0001894866],"category_scores_gemma":[0.001152125,0.00019126,0.0001047183,0.0002974135,0.0001996383,0.000012998,0.0003033099,0.0002839306,0.00007353122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005159216,"about_ca_system_score_gemma":0.0002996656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007841698,"about_ca_topic_score_gemma":0.00004905032,"domain_scores_codex":[0.9978094,0.0002902574,0.0003421718,0.0006934882,0.0004013252,0.0004634153],"domain_scores_gemma":[0.9983886,0.00007464973,0.0001577819,0.00075799,0.0004015018,0.0002194047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001652864,0.00006379202,0.001842022,0.00001357476,0.00002487451,0.00003440135,0.0001138124,0.000008111704,0.9851771,0.000001170377,0.01086332,0.0002049564],"study_design_scores_gemma":[0.0002313983,0.001063037,0.02696876,0.00002882683,0.000005916668,0.00005859551,0.00007588162,0.000007293424,0.9400997,0.00001177755,0.03124381,0.0002050212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972241,0.0000167153,0.000438612,0.0003483261,0.0008040571,0.0004770765,0.00003881744,0.00003546826,0.0006168482],"genre_scores_gemma":[0.9954415,0.000003166657,0.0001859924,0.0001431619,0.000855041,0.00004315723,0.00009775164,0.00005282252,0.003177412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04507743,"threshold_uncertainty_score":0.7799358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183362071272984,"score_gpt":0.251588671817031,"score_spread":0.2397550511043012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}