{"id":"W2887072002","doi":"10.1016/j.celrep.2018.07.023","title":"Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; European Research Council; Medical Research Council; Medical Research Council Canada; Gottfried und Julia Bangerter-Rhyner-Stiftung; Associazione Italiana per la Ricerca sul Cancro; Seventh Framework Programme; Ministero dell’Istruzione, dell’Università e della Ricerca; Novartis Stiftung für Medizinisch-Biologische Forschung; Alzheimer's Society; Universitätsspital Basel; Universität Basel; Alzheimer’s Research UK; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis Foundation; Mach-Gaensslen Foundation of Canada; Desert Research Institute","keywords":"Mitochondrion; Cell biology; Tauopathy; Biology; Neuroscience; Neuron; Mitochondrial fission; Organelle; Cytokine; Mitophagy; Neurodegeneration; Apoptosis; Disease; Immunology; Medicine; Pathology; Autophagy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001461374,0.0005343235,0.0002535506,0.0002199215,0.000170026,0.0002920562,0.0001081519,0.0003108804,0.001102682],"category_scores_gemma":[0.0001100499,0.00009488051,0.0002944385,0.0001147123,0.0001966407,0.0002082737,0.0003682518,0.0005942477,0.0003780597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003207203,"about_ca_system_score_gemma":0.0001660887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000345896,"about_ca_topic_score_gemma":0.0007854122,"domain_scores_codex":[0.9998457,0.00002221297,0.00001489424,0.00002508258,0.0000554295,0.00003660635],"domain_scores_gemma":[0.9998989,0.00001270089,0.00003174811,0.00001374429,0.00001614475,0.00002681026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006043853,0.00001391137,0.0001569041,0.00002469019,0.000004740431,0.0001050808,0.00001233437,0.00002984014,0.9983637,0.00009024418,0.00004264606,0.001095457],"study_design_scores_gemma":[0.0000235087,0.0003121984,0.007331481,0.00001274173,0.00001684559,0.0008270613,0.00006083358,0.0005586957,0.9865183,0.0002041676,0.004126522,0.000007669611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888697,0.003067579,0.004705788,0.0002890626,0.00007231275,0.00004590292,0.0004751456,0.0001269675,0.002347604],"genre_scores_gemma":[0.9944107,0.001633271,0.001688968,0.00006244602,0.000014934,0.00003755936,0.0003503787,0.0000111861,0.001790642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001102682,"threshold_uncertainty_score":0.003688872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183362071272984,"score_gpt":0.251588671817031,"score_spread":0.2397550511043012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}