{"id":"W2887073019","doi":"10.1007/s00424-018-2182-4","title":"Loss of barrier integrity in alveolar epithelial cells downregulates ENaC expression and activity via Ca2+ and TRPV4 activation","year":2018,"lang":"en","type":"article","venue":"Pflügers Archiv - European Journal of Physiology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Epithelial sodium channel; Cell biology; Chemistry; Downregulation and upregulation; TRPV4; Tight junction; Intracellular; Mechanosensitive channels; Epithelium; Ion channel; Biology; Receptor; Biochemistry; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005107234,0.0001527148,0.0003099258,0.0001873937,0.0001029132,0.00001318073,0.0001870306,0.00004072558,0.00004505034],"category_scores_gemma":[0.0001800956,0.0001084871,0.000069577,0.0001059156,0.0007195481,0.0002596601,0.000142701,0.0004239453,0.000003876546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001341723,"about_ca_system_score_gemma":0.00003475139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001575759,"about_ca_topic_score_gemma":0.000001430046,"domain_scores_codex":[0.9978808,0.001150105,0.0003530781,0.0002592113,0.0001412634,0.0002156102],"domain_scores_gemma":[0.9990157,0.000283561,0.0004229065,0.0001038213,0.00005680146,0.0001171335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005443278,0.00006880344,0.00005258837,0.0000248558,0.000005848985,0.000009947947,0.00179773,0.00004451058,0.987237,0.00001479594,0.00004091902,0.01015864],"study_design_scores_gemma":[0.0007149537,0.0006040527,0.01697425,0.00008457966,0.000005305116,0.00003345893,0.00008087963,0.0004001222,0.9799697,0.0006788133,0.0003455422,0.0001083212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982348,0.0000173526,0.0009327358,0.0001263844,0.0003751808,0.00008055633,0.00001099956,0.000005634391,0.0002163325],"genre_scores_gemma":[0.9990912,0.0002012085,0.0002460764,0.00007310431,0.0003443086,3.390684e-7,4.881963e-7,0.00001720599,0.00002604832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01692166,"threshold_uncertainty_score":0.4423975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0175398385598093,"score_gpt":0.2460393311917614,"score_spread":0.2284994926319521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}