{"id":"W2887142892","doi":"10.1101/392092","title":"MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; University of Toronto; Centre for Addiction and Mental Health; Genome British Columbia; Canada's Michael Smith Genome Sciences Centre; University of British Columbia; University of Victoria","funders":"European Social Fund; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Canadian Cancer Society Research Institute; Warren Y. Soper Charitable Trust; Fondation De Famille Alvin Segal; Centro de Investigación Biomédica en Red de Cáncer; Terry Fox Research Institute; Max-Planck-Gesellschaft; Genome British Columbia; Leading Edge Endowment Fund; McGill University; Institució Catalana de Recerca i Estudis Avançats; Ministerio de Economía y Competitividad; Jewish General Hospital; Generalitat de Catalunya; European Regional Development Fund; Fundación Cellex; European Commission; Deutsche Forschungsgemeinschaft; University of Victoria; Genome Canada","keywords":"MECP2; Gene isoform; Biology; Chromatin; DNA; Rett syndrome; Genetics; Gene; Cell biology; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008601164,0.0002171631,0.0001402531,0.0002000024,0.0001567592,0.0002761971,0.0001645097,0.0002363228,0.00128943],"category_scores_gemma":[0.0001728428,0.00009892305,0.0002051496,0.0001542972,0.0001538121,0.0001662755,0.0001639863,0.0003206671,0.0003328444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001882873,"about_ca_system_score_gemma":0.0001017777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006094298,"about_ca_topic_score_gemma":0.0007929414,"domain_scores_codex":[0.9998647,0.000009402864,0.00001142571,0.00005862075,0.0000329199,0.00002291655],"domain_scores_gemma":[0.9998823,0.00002241425,0.00003976832,0.00001019867,0.0000156143,0.00002963741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005565742,0.000004935309,0.0008297018,0.00001677932,0.000005125728,0.00006924544,0.000006169154,0.00001943677,0.9984297,0.00002905415,0.00002295707,0.000511077],"study_design_scores_gemma":[0.0000172175,0.0001159812,0.08099096,0.0000105842,0.00003729489,0.002636563,0.00006802299,0.001599175,0.9087642,0.0001200226,0.005627946,0.00001210121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946468,0.001642739,0.00207985,0.00007914344,0.00003132402,0.000008632196,0.0007032036,0.00003463798,0.0007736036],"genre_scores_gemma":[0.9927937,0.0005472005,0.001981613,0.0001007672,0.00001636761,0.00002296526,0.001306221,0.00002514382,0.003206135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00128943,"threshold_uncertainty_score":0.004313588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008856207573577727,"score_gpt":0.2123390621506545,"score_spread":0.2034828545770768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}