{"id":"W2887159463","doi":"10.1158/1538-7445.am2018-1751","title":"Abstract 1751: MSC-1 is a first-in-class humanized monoclonal antibody that modulates the tumor microenvironment by inhibiting a novel cancer immunotherapy target, LIF","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Cancer research; Tumor microenvironment; Leukemia inhibitory factor; Cancer; Immunotherapy; Tumor progression; Medicine; Biology; Immunology; Cytokine; Internal medicine; Interleukin 6","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001780927,0.0007213771,0.0003198171,0.0004602035,0.0002058384,0.0003227007,0.0005804097,0.000663372,0.005861762],"category_scores_gemma":[0.000107872,0.0001165818,0.0003538292,0.0001714343,0.0002128184,0.0002217726,0.0002014967,0.00113155,0.001848948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007982061,"about_ca_system_score_gemma":0.0006173972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001241414,"about_ca_topic_score_gemma":0.001118286,"domain_scores_codex":[0.9998462,0.00001753425,0.000008347252,0.00002897373,0.00005092289,0.00004803412],"domain_scores_gemma":[0.9999205,0.00001022846,0.00001449244,0.000005119701,0.00001650279,0.0000331409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006833472,0.0004934481,0.0005746162,0.000168486,0.00003902176,0.0001884382,0.00003067735,0.0003511962,0.9689606,0.0009320859,0.003016699,0.02456136],"study_design_scores_gemma":[0.0003478325,0.002382065,0.004060656,0.00002674963,0.00009506958,0.001017732,0.00001651006,0.001505014,0.9405812,0.0001271213,0.04982736,0.00001268909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9208369,0.0248953,0.01434939,0.002495537,0.0007586601,0.0007234947,0.003118315,0.001095281,0.03172709],"genre_scores_gemma":[0.9508545,0.005275195,0.007258901,0.0007625043,0.0002481719,0.0003264031,0.004594752,0.00007094943,0.03060867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005861762,"threshold_uncertainty_score":0.01960951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07485835641612114,"score_gpt":0.3935851950193582,"score_spread":0.318726838603237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}