{"id":"W2887170399","doi":"10.1186/s12977-018-0440-3","title":"Selective resistance profiles emerging in patient-derived clinical isolates with cabotegravir, bictegravir, dolutegravir, and elvitegravir","year":2018,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; BC Children's Hospital; Jewish General Hospital","funders":"Université de Montréal; McGill University; Genome Canada; Gilead Sciences","keywords":"Elvitegravir; Dolutegravir; Raltegravir; Integrase inhibitor; Virology; Biology; Integrase; Drug resistance; Microbiology; Medicine; Viral load; Virus; Human immunodeficiency virus (HIV); Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000303269,0.0002349749,0.0003637903,0.0002105269,0.0001956754,0.0004768065,0.0002136778,0.000397689,0.001453015],"category_scores_gemma":[0.0005895313,0.000106267,0.0002263456,0.0003265005,0.0001716213,0.0001540064,0.000164703,0.0005762724,0.0003414333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002843729,"about_ca_system_score_gemma":0.0001996113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009809863,"about_ca_topic_score_gemma":0.001315166,"domain_scores_codex":[0.9996336,0.00006186789,0.00004660943,0.0001061712,0.00008840278,0.00006332448],"domain_scores_gemma":[0.9996284,0.00008906611,0.00007728603,0.00004336606,0.00009443535,0.00006738751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001976047,0.0005247263,0.0904489,0.000116018,0.00007018334,0.001049323,0.000533897,0.0004656137,0.8886674,0.0001365292,0.0004637367,0.01554768],"study_design_scores_gemma":[0.0001984222,0.008869844,0.3929004,0.00005204595,0.0002037724,0.01372004,0.00102472,0.002530898,0.575518,0.0001711949,0.004770176,0.00004052743],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986293,0.0002211296,0.0002319107,0.00002349443,0.000003670121,0.0000278281,0.0003903956,0.00001327807,0.0004591003],"genre_scores_gemma":[0.9970046,0.000160746,0.001051489,0.00005102836,0.00000574607,0.00003194007,0.001171174,0.000008299575,0.0005150523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001453015,"threshold_uncertainty_score":0.004860818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01119201152111467,"score_gpt":0.2854821367145856,"score_spread":0.274290125193471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}