{"id":"W2887175631","doi":"10.1021/acsinfecdis.8b00136","title":"GW779439X and Its Pyrazolopyridazine Derivatives Inhibit the Serine/Threonine Kinase Stk1 and Act As Antibiotic Adjuvants against β-Lactam-Resistant <i>Staphylococcus aureus</i>","year":2018,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; Wellcome Trust; Structural Genomics Consortium; University of Wisconsin-Madison; Pharmaceutical Research and Manufacturers of America Foundation; Hartwell Foundation; Wellcome; GlaxoSmithKline; U.S. Department of Veterans Affairs","keywords":"Microbiology; Threonine; Staphylococcus aureus; Antibiotics; Serine; Penicillin binding proteins; Penicillin; Kinase; Biology; Methicillin-resistant Staphylococcus aureus; Biochemistry; Bacteria; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008738475,0.0003092366,0.0002464424,0.0001770574,0.0001114749,0.0002139155,0.0002043338,0.0002243774,0.001922574],"category_scores_gemma":[0.00007224242,0.0001192342,0.0002712844,0.000166547,0.000173772,0.0001754312,0.0001758666,0.0004273729,0.0004899615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002979687,"about_ca_system_score_gemma":0.0002546643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006998525,"about_ca_topic_score_gemma":0.001786133,"domain_scores_codex":[0.9999385,0.00000834889,0.000005368671,0.0000108914,0.00001877773,0.00001810261],"domain_scores_gemma":[0.9999751,0.000002653239,0.00001033564,0.000002404401,0.000002783313,0.000006688166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006065579,0.0001454012,0.0007655777,0.0003478047,0.00006643739,0.0004400242,0.0000289046,0.00342472,0.9388075,0.001860849,0.001463685,0.05204244],"study_design_scores_gemma":[0.0005305301,0.004146956,0.00488455,0.00003277861,0.0001022918,0.001305229,0.00003873573,0.003591797,0.9461732,0.00057893,0.03858106,0.00003386167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662057,0.0104839,0.00814988,0.0008412327,0.0001773856,0.0002744205,0.00154074,0.0003280582,0.01199874],"genre_scores_gemma":[0.9839813,0.005234741,0.005368132,0.0001831257,0.00001639443,0.00009881319,0.001182845,0.0000272341,0.003907348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001922574,"threshold_uncertainty_score":0.006431639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009433211203008903,"score_gpt":0.2655377982894059,"score_spread":0.256104587086397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}