{"id":"W2887175631","doi":"10.1021/acsinfecdis.8b00136","title":"GW779439X and Its Pyrazolopyridazine Derivatives Inhibit the Serine/Threonine Kinase Stk1 and Act As Antibiotic Adjuvants against β-Lactam-Resistant <i>Staphylococcus aureus</i>","year":2018,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; Wellcome Trust; Structural Genomics Consortium; University of Wisconsin-Madison; Pharmaceutical Research and Manufacturers of America Foundation; Hartwell Foundation; Wellcome; GlaxoSmithKline; U.S. Department of Veterans Affairs","keywords":"Microbiology; Threonine; Staphylococcus aureus; Antibiotics; Serine; Penicillin binding proteins; Penicillin; Kinase; Biology; Methicillin-resistant Staphylococcus aureus; Biochemistry; Bacteria; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002300986,0.0006502791,0.000759554,0.0002449723,0.0007598951,0.0001857209,0.0002263532,0.0001871659,0.0000973334],"category_scores_gemma":[0.001307528,0.0004785174,0.0001495946,0.00069079,0.00125581,0.0003531316,0.0003608786,0.0004017269,0.00008267294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001228786,"about_ca_system_score_gemma":0.0002908888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008043674,"about_ca_topic_score_gemma":0.0002899377,"domain_scores_codex":[0.9971808,0.0001308581,0.0005589568,0.0008784502,0.0004671982,0.0007837983],"domain_scores_gemma":[0.9975736,0.0003927333,0.0003110843,0.0007202146,0.0004593329,0.0005429958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002243538,0.001052285,0.3089136,0.0008607952,0.0007005226,0.0005709404,0.0007294639,0.000007752234,0.6689253,0.001155737,0.005906029,0.00893398],"study_design_scores_gemma":[0.006815657,0.002866088,0.7578229,0.001364261,0.001039705,0.0001293025,0.0005920646,0.000130374,0.2136291,0.000763287,0.01349478,0.001352474],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866313,0.006672212,0.00001747027,0.001167844,0.0002773651,0.001291675,0.0002008733,0.0003348375,0.003406476],"genre_scores_gemma":[0.9939562,0.002427343,0.00003188594,0.002424453,0.0006441185,0.00003554048,0.00004852137,0.0001078063,0.0003240974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4552962,"threshold_uncertainty_score":0.9997666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009433211203008903,"score_gpt":0.2655377982894059,"score_spread":0.256104587086397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}