{"id":"W2887246354","doi":"10.1158/1538-7445.am2018-2991","title":"Abstract 2991: Cytoplasmic mislocalization of CTCF by NPM1c in acute myeloid leukemia resulting in inhibited CTCF regulatory functions generating aberrant genetic and epigenetic profiles","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"CTCF; Epigenetics; Biology; Cytoplasm; Cell biology; Molecular biology; Cancer research; Gene expression; Genetics; Gene; Enhancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071344,0.0003397843,0.0003177544,0.0001933385,0.0002339597,0.0002331287,0.0002805759,0.0004695654,0.001844024],"category_scores_gemma":[0.0001854879,0.0001645426,0.0002453026,0.0001346059,0.0003460314,0.0001217997,0.0001969599,0.0007534092,0.0009551793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005713851,"about_ca_system_score_gemma":0.000227439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001075012,"about_ca_topic_score_gemma":0.0007931979,"domain_scores_codex":[0.9998273,0.00002503506,0.00001781513,0.00003083485,0.0000679849,0.00003113888],"domain_scores_gemma":[0.9998413,0.00003670326,0.00004036373,0.00002063918,0.00001673379,0.00004418544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004726249,0.00001982805,0.0001108613,0.00001409563,0.000002106821,0.0001883167,0.000004191872,0.00004938072,0.9991816,0.00007284049,0.00005008436,0.0002594441],"study_design_scores_gemma":[0.00002913156,0.0001509661,0.005244472,0.000006239477,0.000009002789,0.00187448,0.00002462314,0.002917537,0.9873032,0.00008004113,0.002353894,0.000006342486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939914,0.0005034789,0.003613419,0.0001878523,0.00005047218,0.00002667447,0.0005183084,0.00006346164,0.001044923],"genre_scores_gemma":[0.9944745,0.0001997338,0.002099599,0.00008173585,0.00001097237,0.00003628425,0.0008909455,0.00003421803,0.002171973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001844024,"threshold_uncertainty_score":0.006168842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03573272656724166,"score_gpt":0.3478233118408166,"score_spread":0.3120905852735749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}