{"id":"W2887294293","doi":"10.1172/jci.insight.120877","title":"β Cell dysfunction exists more than 5 years before type 1 diabetes diagnosis","year":2018,"lang":"en","type":"article","venue":"JCI Insight","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Diabetes Canada","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institutes of Health; George and Frances Ball Foundation; National Institute of Child Health and Human Development; School of Medicine, Indiana University; U.S. Department of Veterans Affairs; Ball Brothers Foundation; Juvenile Diabetes Research Foundation International","keywords":"Type 2 diabetes; Medicine; Diabetes mellitus; Internal medicine; Intensive care medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008468824,0.00036967,0.0005041617,0.0007042385,0.0007933027,0.0008959524,0.0002931777,0.0006663269,0.001636449],"category_scores_gemma":[0.001870617,0.0002021688,0.0004280214,0.0008425151,0.0002934719,0.0006463107,0.0005830078,0.0007622259,0.0002716569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003460351,"about_ca_system_score_gemma":0.000373296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002609906,"about_ca_topic_score_gemma":0.002902897,"domain_scores_codex":[0.9994258,0.00008707373,0.00005828986,0.0001734114,0.00009138626,0.0001641787],"domain_scores_gemma":[0.9975021,0.000265931,0.001405185,0.0001189308,0.0001593125,0.0005485152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004177499,0.00004489656,0.9961975,0.00001505472,0.00003985102,0.0002145471,0.00006961153,0.00002519869,0.0003288829,0.00002051697,0.00004389076,0.0025823],"study_design_scores_gemma":[0.00000392784,0.0002346165,0.9988068,0.00001322647,0.00003143484,0.0005094509,0.00008112817,0.00002335431,0.00005582301,0.0000258294,0.0002115902,0.000002773836],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997867,0.001224376,0.0000766176,0.00004246689,0.0000161784,0.000004854037,0.0001850638,0.000004793992,0.0005785703],"genre_scores_gemma":[0.999102,0.0002945229,0.00005462021,0.00003270068,0.00001896533,0.000003126023,0.0002944746,0.000001445744,0.000198236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002609906,"threshold_uncertainty_score":0.005474448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006308586832299522,"score_gpt":0.2201124700084767,"score_spread":0.2138038831761772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}