{"id":"W2887304191","doi":"10.1158/1538-7445.am2018-3914","title":"Abstract 3914: ZW49, a HER2-targeted biparatopic antibody-drug conjugate for the treatment of HER2-expressing cancers","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Antibody-drug conjugate; Trastuzumab; Medicine; In vivo; Antibody; Cancer research; Cancer; Conjugate; Therapeutic index; Cytotoxicity; In vitro; Pharmacology; Breast cancer; Drug; Monoclonal antibody; Immunology; Internal medicine; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009799478,0.0003411365,0.0001397554,0.0002681587,0.00007826208,0.0001609875,0.0002003175,0.0002827481,0.00256114],"category_scores_gemma":[0.00006755648,0.00008925405,0.000172186,0.0001100013,0.00008290844,0.0001973927,0.0001682713,0.0002712526,0.0007547896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002187654,"about_ca_system_score_gemma":0.0001576332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003164662,"about_ca_topic_score_gemma":0.000301476,"domain_scores_codex":[0.9999477,0.000009550864,0.000003997368,0.000008469461,0.00002017321,0.00001007019],"domain_scores_gemma":[0.9999739,0.000002633668,0.000009478035,0.000001805199,0.000004929958,0.000007211018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002531928,0.0001083147,0.0001633174,0.00006878501,0.00001527178,0.0001309689,0.000008804942,0.0004248552,0.9877018,0.0002916656,0.0005963728,0.01023662],"study_design_scores_gemma":[0.0001694602,0.002080956,0.001679597,0.00001042961,0.00002696117,0.0006856561,0.000005799345,0.001525748,0.9835106,0.00007390837,0.01022445,0.000006418059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9664046,0.007876926,0.01293631,0.0003875005,0.0001767533,0.0003344566,0.0008949405,0.0002631096,0.01072548],"genre_scores_gemma":[0.9819925,0.002870042,0.004712129,0.0001452131,0.00003937497,0.00008451733,0.001163634,0.00002999898,0.008962617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00256114,"threshold_uncertainty_score":0.008567929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1187842900204149,"score_gpt":0.472216537494243,"score_spread":0.3534322474738281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}