{"id":"W2887351230","doi":"10.1158/1538-7445.am2018-2377","title":"Abstract 2377: Design, synthesis, and characterization of 4-aminopyrazole quinazolines as potent inhibitors of G protein-coupled receptor kinase GRK6 for the potential treatment of multiple myeloma","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"","keywords":"Kinome; G protein-coupled receptor kinase; Kinase; Gene silencing; Cancer research; Quinazoline; Biology; Chemistry; Pharmacology; Cell biology; Signal transduction; Biochemistry; Gene; G protein-coupled receptor; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001575647,0.000418637,0.0004122316,0.0002912262,0.0001504575,0.0002246784,0.0004930221,0.0002821414,0.002140196],"category_scores_gemma":[0.0001081909,0.0001317202,0.0003148228,0.0002595551,0.0001435673,0.000178495,0.0001488521,0.0003646375,0.0008911633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003291935,"about_ca_system_score_gemma":0.0003787211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009428391,"about_ca_topic_score_gemma":0.001545263,"domain_scores_codex":[0.9999232,0.0000107072,0.000007406632,0.00001262351,0.0000285836,0.00001738874],"domain_scores_gemma":[0.999964,0.0000035064,0.000006990269,0.000002485941,0.00001114146,0.00001189462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002687505,0.0002467473,0.0002051278,0.0003225461,0.00003090025,0.0003821606,0.0000409286,0.00197112,0.9816298,0.0004849709,0.0004691067,0.01394784],"study_design_scores_gemma":[0.0008917289,0.007642215,0.00361896,0.00005318293,0.0001375374,0.0008894994,0.0000547973,0.005953352,0.9610718,0.0002296034,0.01940743,0.00004986421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9592115,0.01144539,0.01548858,0.0004427049,0.0001308789,0.001235814,0.002288074,0.0002530187,0.009504034],"genre_scores_gemma":[0.9787253,0.00606399,0.008188601,0.0001396206,0.00002161058,0.0001641236,0.002013738,0.00002801418,0.004654993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002140196,"threshold_uncertainty_score":0.00715965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04760173757001532,"score_gpt":0.3384234975738504,"score_spread":0.2908217600038351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}