{"id":"W2887353432","doi":"10.1186/s13195-018-0407-6","title":"Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer’s disease","year":2018,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Alzheimer's Association; Chongqing Medical University; Weston Brain Institute; Consortium canadien en neurodégénérescence associée au vieillissement; Alzheimer's Disease Neuroimaging Initiative","keywords":"Neurology; Neuroscience; Cerebrospinal fluid; Cognitive impairment; Disease; Medicine; Degeneration (medical); Pathology; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002283983,0.0003876744,0.0004880293,0.001027813,0.0003256575,0.0001559963,0.0002306854,0.0001998581,0.001152798],"category_scores_gemma":[0.0002690968,0.0003402383,0.000112449,0.001310252,0.0007272625,0.0003404306,0.0002016799,0.0008140295,0.0002162899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001907284,"about_ca_system_score_gemma":0.0007342183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007667598,"about_ca_topic_score_gemma":0.0005178966,"domain_scores_codex":[0.9943203,0.001086228,0.0005748033,0.0009642494,0.001622794,0.001431662],"domain_scores_gemma":[0.997691,0.000234532,0.00008192816,0.0003828291,0.0009685181,0.0006412104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02463321,0.007296627,0.8604645,0.00009194907,0.004132202,0.0007860833,0.005880168,7.108905e-7,0.05676771,0.0003150351,0.002792243,0.03683959],"study_design_scores_gemma":[0.01417332,0.007859051,0.8993313,0.0009168976,0.0002165674,0.00001341438,0.0009358957,0.001458556,0.07353315,0.0005739529,0.0005066415,0.000481229],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781318,0.01201828,0.00001168369,0.003525777,0.00005321767,0.005538917,0.00004110126,0.00004993542,0.0006292994],"genre_scores_gemma":[0.9957537,0.001157148,0.0000855181,0.0008144179,0.0001695539,0.001567991,0.0000975288,0.00006932276,0.0002848266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03886686,"threshold_uncertainty_score":0.999905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08447353320381283,"score_gpt":0.3849543143126986,"score_spread":0.3004807811088857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}