{"id":"W2887377336","doi":"10.1158/1538-7445.am2018-3515","title":"Abstract 3515: Down the rabbit hole with structural effects of FK866 in primary CLL B cells","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Saint-Boniface; University of Manitoba","funders":"","keywords":"Biology; NAD+ kinase; Chlorambucil; Phalloidin; Cell biology; Nicotinamide phosphoribosyltransferase; Bendamustine; Cancer research; Molecular biology; Cytoskeleton; Cell; Biochemistry; Enzyme; Chronic lymphocytic leukemia; Immunology; Leukemia; Chemotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000486349,0.0001278866,0.00014919,0.00007288576,0.000102837,0.0000282641,0.0005135389,0.0001456159,0.00007233502],"category_scores_gemma":[0.00007323662,0.00007866238,0.00005391582,0.0003319331,0.0009557996,0.000004387471,0.0002993724,0.0004275166,0.00001481345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005124842,"about_ca_system_score_gemma":0.0003290036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004552464,"about_ca_topic_score_gemma":0.0002157024,"domain_scores_codex":[0.9982612,0.0001415509,0.0001566425,0.0003830021,0.000520157,0.0005374922],"domain_scores_gemma":[0.9990007,0.0000626277,0.0000369874,0.0004914117,0.0002998051,0.0001084626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004767602,0.00003502808,0.0008031104,0.0001523367,0.00003275772,0.00001192796,0.00006208587,0.000006221791,0.9918826,0.0000189177,0.002370695,0.004147596],"study_design_scores_gemma":[0.0007155578,0.0004490183,0.01302903,0.00007740343,0.000003609607,0.000002363706,0.00002434071,0.000005989362,0.9785012,0.00005302639,0.007030239,0.0001081956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952728,0.0018145,0.0000191046,0.0003233178,0.00006017392,0.0004736038,0.00001367521,0.000003988317,0.002018847],"genre_scores_gemma":[0.99845,0.0002915626,0.00007190791,0.0001352184,0.0002721918,0.00009978023,0.00002181722,0.00002319318,0.0006343342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01338134,"threshold_uncertainty_score":0.3521683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01521171862019545,"score_gpt":0.3342167614600169,"score_spread":0.3190050428398215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}