{"id":"W2887419375","doi":"10.1038/s41467-018-08190-x","title":"A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institutes of Health; National Cancer Institute; Canadian Institutes of Health Research; Canada Research Chairs; National Institute of Allergy and Infectious Diseases; McMaster University","keywords":"Salmonella; Intracellular; Macrophage; Microbiology; Biology; Chemistry; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004342962,0.0001795892,0.000294107,0.00002530851,0.0003430457,0.00007790345,0.001136885,0.0004332503,0.0001456998],"category_scores_gemma":[0.0001577708,0.0000864438,0.0001754307,0.0003414656,0.0001347234,0.00009512274,0.0001891879,0.0005268417,0.00009964297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004139764,"about_ca_system_score_gemma":0.00002257895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001062379,"about_ca_topic_score_gemma":0.0006018451,"domain_scores_codex":[0.9986517,0.0002986774,0.00028912,0.0003309854,0.0001157715,0.0003136884],"domain_scores_gemma":[0.9976391,0.001413555,0.0001650627,0.0004591178,0.0002454733,0.00007768034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001808533,0.0002060455,0.03977495,0.000009725393,0.00005877823,6.401294e-7,0.00004920453,0.000008042547,0.9440947,0.002622041,0.01073932,0.002255699],"study_design_scores_gemma":[0.001132576,0.0005807126,0.541511,0.0000507662,0.0001003477,0.00001451158,0.0002295458,0.002128936,0.04176553,0.002526497,0.409225,0.0007346037],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894286,0.001947344,0.00003063453,0.004877401,0.0005079367,0.0007401918,0.0002399396,0.0001253293,0.002102659],"genre_scores_gemma":[0.9957453,0.00009064067,0.001202588,0.0008527637,0.0002440541,0.00005368781,0.001429874,0.00000325444,0.0003778602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9023291,"threshold_uncertainty_score":0.3525076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02175839107153965,"score_gpt":0.2746679707824592,"score_spread":0.2529095797109196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}