{"id":"W2887426924","doi":"10.3390/molecules23082041","title":"Evaluation of Nitrobenzyl Derivatives of Camptothecin as Anti-Cancer Agents and Potential Hypoxia Targeting Prodrugs","year":2018,"lang":"en","type":"article","venue":"Molecules","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"University of Manitoba; Manitoba Medical Service Foundation","keywords":"Prodrug; Camptothecin; SN-38; Chemistry; Cytotoxicity; Topoisomerase; Combinatorial chemistry; Tirapazamine; Stereochemistry; Pharmacology; Conjugate; IC50; Nitro; Enzyme; In vitro; Biochemistry; Organic chemistry; Biology; Cancer; Irinotecan","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003979064,0.0001233592,0.000176567,0.00004957645,0.0000512599,0.000008767531,0.0001002785,0.00008137237,0.00007467135],"category_scores_gemma":[0.0001756393,0.000116385,0.00005824151,0.00007489822,0.0002058608,0.000005651214,0.00008251773,0.00003607911,0.000001407115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007319139,"about_ca_system_score_gemma":0.00013595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008817268,"about_ca_topic_score_gemma":0.00001807024,"domain_scores_codex":[0.9989274,0.0001166712,0.0002217424,0.0002658899,0.000312134,0.0001562171],"domain_scores_gemma":[0.9990906,0.00000374085,0.0001825178,0.000178081,0.0005028316,0.0000422221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000500857,0.00004039154,0.0007987287,0.00002636658,0.00009133061,9.379352e-8,0.0002479191,0.00008479982,0.988397,0.00002717143,0.0007715423,0.009464576],"study_design_scores_gemma":[0.0007861612,0.0001304959,0.0166893,0.00002522139,0.0001188392,0.000002324868,0.0001662329,0.0003467917,0.9781391,0.000159623,0.003308066,0.0001278253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994013,0.004367463,0.0005318274,0.00003696797,0.0002850609,0.0002307974,0.00003168044,0.00000457155,0.0004986309],"genre_scores_gemma":[0.9978135,0.0006730616,0.0007473992,0.00006994939,0.0005319812,0.00002178791,0.00002707074,0.00001861092,0.00009663912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01589057,"threshold_uncertainty_score":0.4746042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0162771929075227,"score_gpt":0.2931220774034706,"score_spread":0.2768448844959479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}