{"id":"W2887426924","doi":"10.3390/molecules23082041","title":"Evaluation of Nitrobenzyl Derivatives of Camptothecin as Anti-Cancer Agents and Potential Hypoxia Targeting Prodrugs","year":2018,"lang":"en","type":"article","venue":"Molecules","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"University of Manitoba; Manitoba Medical Service Foundation","keywords":"Prodrug; Camptothecin; SN-38; Chemistry; Cytotoxicity; Topoisomerase; Combinatorial chemistry; Tirapazamine; Stereochemistry; Pharmacology; Conjugate; IC50; Nitro; Enzyme; In vitro; Biochemistry; Organic chemistry; Biology; Cancer; Irinotecan","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404279,0.0002978469,0.000217166,0.000152371,0.0000747731,0.0001046149,0.0002509099,0.0002288008,0.0009287316],"category_scores_gemma":[0.0001850293,0.0001140634,0.000126519,0.0001493553,0.0001092754,0.0001413993,0.00008593368,0.0003097269,0.0002009354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002312772,"about_ca_system_score_gemma":0.0001691744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007326489,"about_ca_topic_score_gemma":0.001634916,"domain_scores_codex":[0.9999058,0.00002292795,0.000007650814,0.00001583134,0.00003274182,0.00001505577],"domain_scores_gemma":[0.9999173,0.00001813641,0.00002181325,0.000006775776,0.00002208874,0.0000139944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001399955,0.00007132155,0.00007085688,0.00009318323,0.000005478651,0.00007287368,0.00002333799,0.0005262004,0.9952878,0.0001050541,0.00003445722,0.003569502],"study_design_scores_gemma":[0.00003011003,0.001970413,0.0006013043,0.000009366733,0.00001260259,0.000196441,0.00001848044,0.0008947104,0.9937844,0.00002697988,0.002450586,0.000004658952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921563,0.002545791,0.002255587,0.00007108928,0.00002210403,0.0001047356,0.0001992874,0.00003814065,0.002606881],"genre_scores_gemma":[0.9874753,0.003016901,0.005869486,0.00005980595,0.000009398255,0.00006677915,0.0003623779,0.00001453542,0.003125351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009287316,"threshold_uncertainty_score":0.003106892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0162771929075227,"score_gpt":0.2931220774034706,"score_spread":0.2768448844959479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}