{"id":"W2887473262","doi":"10.1002/clc.23049","title":"Consistent LDL‐C response with evolocumab among patient subgroups in PROFICIO: A pooled analysis of 3146 patients from phase 3 studies","year":2018,"lang":"en","type":"article","venue":"Clinical Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"European Society of Cardiology; Amgen","keywords":"Evolocumab; Medicine; PCSK9; Placebo; Internal medicine; Regimen; Alirocumab; Dosing; Adverse effect; Diabetes mellitus; Demography; Hypertriglyceridemia; Gastroenterology; Lipoprotein; Endocrinology; Cholesterol; Triglyceride","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03290191,0.00226263,0.01113449,0.002522358,0.0004167296,0.002882683,0.0009788936,0.001634188,0.001756935],"category_scores_gemma":[0.03229426,0.001242105,0.03240655,0.003058568,0.0007509445,0.00143191,0.001391212,0.001105864,0.0002583028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000801128,"about_ca_system_score_gemma":0.0009382622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007317638,"about_ca_topic_score_gemma":0.001883913,"domain_scores_codex":[0.968205,0.02082439,0.0051951,0.002742831,0.002459652,0.0005728819],"domain_scores_gemma":[0.9696593,0.0176621,0.008430002,0.002648567,0.001210413,0.000389677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.06008061,0.00008075232,0.04866759,0.01403681,0.8579645,0.0001830123,0.0001426014,0.001340229,0.001699466,0.00007841419,0.0007024604,0.01502353],"study_design_scores_gemma":[0.01603514,0.003521063,0.08471498,0.001170674,0.8900822,0.0003134819,0.0001121062,0.0009965228,0.0006095963,0.0005420209,0.001806059,0.00009617346],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5550776,0.4197766,0.01007158,0.000698428,0.0005498488,0.002288835,0.008664608,0.0002948395,0.002577618],"genre_scores_gemma":[0.979234,0.01327004,0.002563918,0.0005356119,0.0001710094,0.001170969,0.002688151,0.00006301761,0.0003033191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03290191,"threshold_uncertainty_score":0.174004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05005643842866261,"score_gpt":0.3897345328225613,"score_spread":0.3396780943938987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}