{"id":"W2887481850","doi":"10.18433/jpps29322","title":"Calcium Signal Pathway is Involved in Prostaglandin E2 Induced Cardiac Fibrosis in Cardiac Fibroblasts","year":2018,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"CTGF; Arachidonic acid; Prostaglandin E2 receptor; Cardiac fibrosis; Downregulation and upregulation; Fibrosis; Fibronectin; Prostaglandin E2; Chemistry; Calcium in biology; Western blot; Signal transduction; Immunostaining; Connective tissue; Cell biology; Endocrinology; Prostaglandin; Internal medicine; Receptor; Growth factor; Biology; Medicine; Agonist; Biochemistry; Pathology; Cell; Immunohistochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001386882,0.0003447986,0.0002093044,0.0002337375,0.0002908499,0.0002463984,0.0001054997,0.0003274688,0.001699792],"category_scores_gemma":[0.0001033212,0.0001271908,0.0003016154,0.0001531978,0.000256001,0.0002965672,0.0001535019,0.0004683748,0.0002781301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002348645,"about_ca_system_score_gemma":0.0002530927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004853804,"about_ca_topic_score_gemma":0.0006441944,"domain_scores_codex":[0.9999173,0.00001748412,0.000008645786,0.00001564157,0.00001859929,0.00002230374],"domain_scores_gemma":[0.9999366,0.00001233073,0.00001815325,0.000005620548,0.00001269522,0.0000145542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008183997,0.00009061985,0.001199604,0.0002703258,0.00001183296,0.0009109478,0.0000583293,0.00006035312,0.9942287,0.0003915958,0.00009673546,0.001862512],"study_design_scores_gemma":[0.0003019311,0.0008313784,0.06233365,0.00008362014,0.0001362328,0.003333696,0.0003254194,0.001998125,0.923694,0.001031388,0.00590723,0.00002335938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778627,0.01124454,0.005393106,0.0005092004,0.0001059644,0.0001305321,0.0004520806,0.00007308753,0.00422884],"genre_scores_gemma":[0.9897617,0.005016283,0.001851248,0.0001208196,0.00003177582,0.0001173581,0.0002655979,0.000004994547,0.002830292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001699792,"threshold_uncertainty_score":0.005686402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07209792742302963,"score_gpt":0.3832728071875114,"score_spread":0.3111748797644818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}