{"id":"W2887504455","doi":"10.1038/s41590-018-0178-z","title":"Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency","year":2018,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Center for Research Resources; National Heart, Lung, and Blood Institute; National Health and Medical Research Council; National Cancer Institute; Exzellenzclusters Entzündungsforschung; Shanghai Educational Development Foundation; Institut National de la Santé et de la Recherche Médicale; Stony Wold-Herbert Fund; Deutsche Forschungsgemeinschaft; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Helmut Horten Stiftung; Institute for Research in Biomedicine; Jeffrey Modell Foundation; National Science Foundation; National Institute of Allergy and Infectious Diseases; Medical Research Council; Université Paris Descartes; St. Giles Foundation; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche","keywords":"Immunology; Biology; Mycobacterium tuberculosis; Antigen; Mycobacterium leprae; Mycobacterium bovis; Immune system; Tuberculosis; Virology; Medicine; Leprosy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000386914,0.0002642331,0.0005161888,0.0003612587,0.0002800715,0.00001700081,0.0004297461,0.001176665,0.0003189041],"category_scores_gemma":[0.00006824333,0.0002574394,0.00007408122,0.0003160917,0.001317463,0.0002304007,0.0001393453,0.0009247098,0.00008343558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003611925,"about_ca_system_score_gemma":0.00005364041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002401407,"about_ca_topic_score_gemma":0.00003417189,"domain_scores_codex":[0.9979893,0.0003302423,0.000559443,0.0004857968,0.00005090391,0.0005842985],"domain_scores_gemma":[0.9991369,0.00009581238,0.0001927548,0.0004556405,0.0001102095,0.000008720077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001106023,0.0002351366,0.004240172,0.00002199377,0.00004857286,0.000003575845,0.001082246,3.408357e-7,0.977218,0.003468175,0.000009127337,0.0135621],"study_design_scores_gemma":[0.003481946,0.001466232,0.4635786,0.00008517615,0.00007305559,0.00009785293,0.0007633162,0.000002364712,0.522922,0.002081017,0.004954273,0.0004941778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829301,0.01415773,0.00003899989,0.00004070946,0.001530257,0.0002441197,0.00004708826,0.00005337708,0.0009575754],"genre_scores_gemma":[0.9994249,0.00009047917,0.00002540079,0.00006158534,0.00002807736,0.00000967294,0.000196747,0.00002349109,0.0001396879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4593384,"threshold_uncertainty_score":0.9999878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007752624738161511,"score_gpt":0.2551152166203687,"score_spread":0.2473625918822072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}