{"id":"W2887504455","doi":"10.1038/s41590-018-0178-z","title":"Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency","year":2018,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Center for Research Resources; National Heart, Lung, and Blood Institute; National Health and Medical Research Council; National Cancer Institute; Exzellenzclusters Entzündungsforschung; Shanghai Educational Development Foundation; Institut National de la Santé et de la Recherche Médicale; Stony Wold-Herbert Fund; Deutsche Forschungsgemeinschaft; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Helmut Horten Stiftung; Institute for Research in Biomedicine; Jeffrey Modell Foundation; National Science Foundation; National Institute of Allergy and Infectious Diseases; Medical Research Council; Université Paris Descartes; St. Giles Foundation; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche","keywords":"Immunology; Biology; Mycobacterium tuberculosis; Antigen; Mycobacterium leprae; Mycobacterium bovis; Immune system; Tuberculosis; Virology; Medicine; Leprosy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001285511,0.000411802,0.0002097549,0.0004182258,0.0002358703,0.0002927715,0.0002368506,0.0006141766,0.001512905],"category_scores_gemma":[0.0002331954,0.0002155183,0.0002047092,0.0001928557,0.0006371284,0.0001607802,0.0002600118,0.0004383627,0.0003311087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000250089,"about_ca_system_score_gemma":0.000235568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005926376,"about_ca_topic_score_gemma":0.0004882269,"domain_scores_codex":[0.999908,0.00002014178,0.00001525063,0.00002191016,0.00002034658,0.00001438658],"domain_scores_gemma":[0.9998608,0.00003239806,0.00004083518,0.00001339633,0.000009028625,0.00004344379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007902411,0.00005502758,0.002598634,0.00006803247,0.00002319381,0.003916903,0.00006002481,0.0003999888,0.9866642,0.0005657771,0.0002577012,0.004600213],"study_design_scores_gemma":[0.00047414,0.001404613,0.05563435,0.0000596067,0.0002964693,0.06753284,0.0004301422,0.006719368,0.856122,0.002518351,0.008764919,0.00004325806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980155,0.0003665635,0.0009294748,0.0001074444,0.00001481605,0.000007539355,0.00013596,0.00005403198,0.0003685686],"genre_scores_gemma":[0.9987728,0.0001385316,0.0006039153,0.00003155698,0.000007205854,0.000008176234,0.00007947448,0.00001369241,0.0003445629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001512905,"threshold_uncertainty_score":0.005061209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007752624738161511,"score_gpt":0.2551152166203687,"score_spread":0.2473625918822072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}